This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Current literature indicates that cystic fibrosis patients with insulin deficiency and impaired glucose tolerance have an increased morbidity compared to the normal glucose tolerant CF patients. Worsening pulmonary function and weight loss is thought to be related to the catabolic state that is seen in patients with impaired glucose tolerance and insulin deficiency with or without cystic fibrosis. Case reports have shown that cystic fibrosis patients with abnormal glucose levels who do not have diabetes had improvement in both weight and pulmonary function with insulin replacement therapy. The goal of this study is to objectively measure changes in metabolism before and after initiation of insulin treatment and its possible relation to improved pulmonary function and increase weight.
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