This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with cystic fibrosis (CF) exhibit endothelial dysfunction as reflected by decreased small artery elasticity (SAE). A second hypothesis is that other conditions associated with decreased SAE (diabetes, hypertriglyceridemia and inflammation) in people with CF, leads to further decrease of SAE in CF patients. Primary Aim: compare the SAE of cystic fibrosis patients with healthy individuals of similar sex and age. Height and weight will be measured as possible co-variants. Secondary Goals: In CF patients, determine if SAE (1) Differs between subjects with and without impairment of glucose intolerance. (2) Is associated with markers of inflammation. (3) Is associated with plasma lipid profile levels, urine microalbumin. Significance: To our knowledge, this is the first study looking at endothelial dysfunction measured by PWA in patients with CF and its relation to glycemia, inflammation, and dyslipidemia. The information gained may help to predict risk for cardiovascular disease. The availability of a non-invasive, highly sensitive method of detecting early changes related to microvascular and macrovascular disease in patients with CF will allow for early treatment and prevention of confounding co-morbidities.
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