This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to learn how best to overcome Hyperacute Lung Rejection, and specifically to define what are the components and steps of this reaction. Various different transgenic and knockout pig types are becoming available that provide a stepwise study approach. These transgenic and knockout pigs provide us the possibility to answer questions about individual pathways, critical to the understanding of mechanisms involved in xenograft lung hyperacute rejection. Additional drugs can be used to block injury pathways not controlled by the transgene. In the future, therapeutic strategies validated in the pig model will then be applied to large animal models (e.g. pig and baboon), as a final step before eventual clinical application.
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