This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The number of Americans over age 50 with AIDS has increased more than 5-fold. Older adults with HIV have a worse prognosis than their younger counterparts. With advances in antiretroviral therapy, and the graying of the population, the number of HIV-infected older Americans will increase even further, clearly defining a need for age-related interventions. Little is known about the impact of age on functional performance in HIV-infected individuals and whether exercise training can ameliorate the marked physical deconditioning in older HIV-infected patients. Results from the proposed research will begin to identify the critical factors in the complex relationship of aging, HIV, and comorbid disease and their effect on physical functioning. We will conduct a cross-sectional study of 90 HIV-infected adults aged 21 to 50+ years to determine the effect of aging on physical functioning (peak aerobic capacity) and body composition in HIV-infected adults. We hypothesize that older HIV-infected individuals have an accelerated decline in physical functioning that is in part modifiable with exercise rehabilitation interventions.
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