This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Depleted Uranium (DU) Follow-up Program is a clinical surveillance project begun in 1993 to follow veterans of friendly fire incidents and subsequent exposure to DU during the Gulf War. It has since been expanded to include veterans of any cnflict in which DU was used. The veterans are evluated every 2 years for the presence of health effects related to their exposure to DU. We are particularly interested in determining any early indicators of health problems, particularly in the target organs, i.e., the kidney. Blood, urine and semen are collected and subjected to a wide variety of tests. The individual undergoes a physical exam and neurocognitive testing. X-rays are done as needed to determine if any changes in the shape or character of the shrapnel have occurred. A series of questionnaires are completed during the inpatient stay. Comparisons between those with elevated urine uranium and those with 'normal' urine uranium are made with respect to physiologic and pyscholgic parameters.
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