Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Abstract The purpose of the study is to develop therapeutic options for human mastocytosis syndromes. Currently there are no FDA-approved cytoreductive therapies for systemic mastocytosis. We will test the safety and efficacy of STI-571 (imatinib mesylate, Gleevec), an FDA approved medication for the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors, in patients with biopsy-proven systemic mastocytosis of sufficient disease grade to warrant cytoreductive therapy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR018390-04
Application #
7377705
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-04-01
Project End
2007-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
4
Fiscal Year
2006
Total Cost
$4,597
Indirect Cost

  Institution

Name
Cleveland Clinic Lerner
Department
Other Basic Sciences
Type
Schools of Medicine
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195

  Publications

Rose, Jonathan A; Wanner, Nicholas; Cheong, Hoi I et al. (2016) Flow Cytometric Quantification of Peripheral Blood Cell ?-Adrenergic Receptor Density and Urinary Endothelial Cell-Derived Microparticles in Pulmonary Arterial Hypertension. PLoS One 11:e0156940
Kasumov, Takhar; Solomon, Thomas P J; Hwang, Calvin et al. (2015) Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes. Obesity (Silver Spring) 23:1414-21
Alkhouri, N; Eng, K; Cikach, F et al. (2015) Breathprints of childhood obesity: changes in volatile organic compounds in obese children compared with lean controls. Pediatr Obes 10:23-9
Rose, Jonathan A; Erzurum, Serpil; Asosingh, Kewal (2015) Biology and flow cytometry of proangiogenic hematopoietic progenitors cells. Cytometry A 87:5-19
Naples, Robert; Laskowski, Dan; McCarthy, Kevin et al. (2015) Carboxyhemoglobin and methemoglobin in asthma. Lung 193:183-7
Wu, Wei; Bleecker, Eugene; Moore, Wendy et al. (2014) Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data. J Allergy Clin Immunol 133:1280-8
Li, Xingnan; Hawkins, Gregory A; Ampleford, Elizabeth J et al. (2013) Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. J Allergy Clin Immunol 132:313-20.e15
Asosingh, Kewal; Farha, Samar; Lichtin, Alan et al. (2012) Pulmonary vascular disease in mice xenografted with human BM progenitors from patients with pulmonary arterial hypertension. Blood 120:1218-27
Yip, Kathleen; Heinberg, Leslie; Giegerich, Victoria et al. (2012) Equivalent weight loss with marked metabolic benefit observed in a matched cohort with and without type 2 diabetes 12 months following gastric bypass surgery. Obes Surg 22:1723-9
Li, Xingnan; Ampleford, Elizabeth J; Howard, Timothy D et al. (2012) Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. J Allergy Clin Immunol 130:861-8.e7

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