This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chronic Renal Insufficiency (CRI), a silent epidemic affecting more than 10 million Americans and frequently progresses to end stage renal disease (SERD), is also strongly associated with cardiovascular disease (CVD). This has leads to the premise that specific uremic-related risk factors increase the rate of CVD in renal disease. Many patients with CRI succumb to fatal CV events before the need for renal replacement. This observational five-year study was established by the National Institutes of Diabetes, Digestive and Kidney Disease (NIDDK) to gain understanding of the relationship between progressive renal disease and cardiovascular illness. The goals are to examine risk factors for CRI and CVD events among patients with varying severity of CRI and to develop predictive models that will identify high risk sub-varying severity of CRI and to develop predictive models that will identify high risk sub-groups. It is hoped that by identifying these sub-groups, that available preventative treatments can be applied in a timely manner. Also enhanced recognition of etiological factors will permit the development and testing of interventions to reduce the burden of advanced renal failure and CV morbidity and mortality. The Cleveland Clinic Foundation is one of four Cleveland area health centers which comprise the CRIC Cohort of Cleveland (CCF, CWRU, Metro and VA).
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