This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Abstract: The purpose of this sub-study is to learn if a 12-week non-weight bearing bed rest experience leads to subsequent depression. The relationship between exercise and depression is important for study. Exercise is commonly prescribed as part of preventative care and interdisciplinary management of the patient experiencing depression. However, research findings examining the effects of exercise on the clinically depressed and healthy persons are mixed and sound studies are sparse. Generally, the study of voluntary, non-weight bearing activity over a period of 12-weeks on depression would be non-feasible. Monitoring for adherence would be difficult and repeated study of depressed mood might vary by the subject s home environment and other factors that are difficult to control without great cost. The NASA sponsored bed rest study provides a unique opportunity to determine how healthy subjects respond emotionally to enforcement of no weight bearing activity. The sub-study sample shall be recruited from the population on the General Clinical Research Center already recruited for the NASA sponsored bed rest study 'A Quantitative Test of On-Orbit Exercise Countermeasures for Bone Demineralization Using a Bedrest Analog (IRB # 6504). Participants will be drawn from the 24 people already enrolled in the NASA study. Subjects will be asked to complete 3 questionnaires: (1) the Center for Epidemiological Studies Depression Revised scale (CES-DR) used to measure level and frequency of depressive symptoms, (2) the Montgomery-Asberg Depression Rating Scale (MADRS) used as a second-stage screening instrument to assess treatment sensitive change in depressive symptoms, and (3) visual analogue scales (VAS) that will measure feelings of depression and sadness in the past week. This investigation is methodologically sound based on a gold standard. Repeated measures ANOVA will be used to analyze the data.
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