This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.We have observed an excessive number of elevated serum trough serum gentamicin levels in our neonatal intensive care unit (NICU) with our current (traditional) dosing regimen. In order to administer gentamicin in a safe and effective way, its pharmacodynamic properties should be maximized, including achieving optimal peak concentrations while keeping trough concentrations low. To achieve this, extended interval administration of gentamicin has been studied in neonates. This methodology employs a higher dose than the traditional method and a longer dosing interval. To date, neonatal dosing recommendations from these studies, however, continue to be complex and non-uniform. Our study aims to test whether one uniform and simple gentamicin dosing method will achieve optimal drug pharmacodynamics and improve safety. We therefore expect to significantly reduce the number of elevated serum trough gentamicin levels while maximizing its effectiveness.
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