This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Levothyroxine is a thyroid hormone prescribed for the treatment of hypothyroidism and thyroid cancer. Although levothyroxine is well tolerated, its absorption is affected by both food and other medications. To avoid reduced or variable absorption, patients are often advised to take it on an empty stomach. However, the effects of timing of levothyroxine administration are unknown. We would like to study the effect of the timing of levothyroxine administration on serum TSH levels by prescribing its administration after fasting, at bedtime, and with food. If the timing of levothyroxine administration does not significantly affect serum TSH levels, then it is concluded that it is unnecessary for patients to adhere to a rigorous and often inconvenient medication schedule. Patients would then only have to adjust the timing of levothyroxine with respect to other medications without also adjusting it with respect to food consumption.
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