This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cancer survival has increased over the past two decades and continues to rise in many countries. In recent years, several studies including our group have described a range of endocrine and cardiovascular late effects in long-term survivors of childhood cancers. such late effects include obesity and the Metabolic Syndrome. There is little information on the mechanism of obesity in long-term cancer survivors. This project is a pilot study to determine the role of neuropeptides in the development of obesity in cancer survivors treated with cranial irradation with or without surgery. The overarching hypothesis is that childhood cancer survivors exposed to cranial irradiation and/or surgery experiencedisruption in the hypothalamus that increases the risk for the development of the Metabolic syndrome many years after completion of the
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