This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The current diagnosis of Alzheimer's disease is one of comprehensive exclusion of other etiologies of dementia combined with identification of characteristic cognitive dysfunction and a typical temporal profile of progression. In particular, the goal is to exclude the systemic or the many degenerative and the few stable neurological disorders that may induce cognitive dysfunction or dementia. A thorough clinical evaluation has been designed to exclude these other illnesses and confirm over time or with the availability of historical data of progression, the presence of AD. This clinical evaluation was initially identified in the Report of the Work Group on AD comprised of members from the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association. Subsequent studies have shown that this comprehensive clinical evaluation has sensitivity of the order of 90% and specificity of 90% as later confirmed by autopsy. Additionally, the NINCDS-ADRDA proposed evaluation has a high rate of interobserver reliability. Clinical centers which have enrolled as members of the National Alzheimer's Disease Cooperative Study have reported on accuracy of better than 90%. At present, post-mortem autopsy is the only way to confirm a diagnosis of Alzheimer's disease. These studies will examine the feasibility of using various biochemical assays to aid in the ante-mortem diagnosis of Alzheimer's disease. This will be accomplished ex vivo using blood and urine specimens from patients with a diagnosis of probable Alzheimer's disease or mild cognitive impairment and from normal controls.
| Goldman, Noreen; Glei, Dana A; Weinstein, Maxine (2018) Declining mental health among disadvantaged Americans. Proc Natl Acad Sci U S A 115:7290-7295 |
| Nersesian, Paula V; Han, Hae-Ra; Yenokyan, Gayane et al. (2018) Loneliness in middle age and biomarkers of systemic inflammation: Findings from Midlife in the United States. Soc Sci Med 209:174-181 |
| Glei, Dana A; Goldman, Noreen; Ryff, Carol D et al. (2018) Physical Function in U.S. Older Adults Compared With Other Populations: A Multinational Study. J Aging Health :898264318759378 |
| Stephan, Yannick; Sutin, Angelina R; Bayard, Sophie et al. (2018) Personality and sleep quality: Evidence from four prospective studies. Health Psychol 37:271-281 |
| Magidson, Jessica F; Robustelli, Briana L; Seitz-Brown, C J et al. (2017) Activity enjoyment, not frequency, is associated with alcohol-related problems and heavy episodic drinking. Psychol Addict Behav 31:73-78 |
| Boylan, Jennifer Morozink; Robert, Stephanie A (2017) Neighborhood SES is particularly important to the cardiovascular health of low SES individuals. Soc Sci Med 188:60-68 |
| Liebzeit, Daniel; Phelan, Cynthia; Moon, Chooza et al. (2017) Rest-Activity Patterns in Older Adults with Heart Failure and Healthy Older Adults. J Aging Phys Act 25:116-122 |
| Chirinos, Diana A; Murdock, Kyle W; LeRoy, Angie S et al. (2017) Depressive symptom profiles, cardio-metabolic risk and inflammation: Results from the MIDUS study. Psychoneuroendocrinology 82:17-25 |
| Robinette, Jennifer W; Charles, Susan T; Gruenewald, Tara L (2017) Neighborhood Socioeconomic Status and Health: A Longitudinal Analysis. J Community Health 42:865-871 |
| Sloan, Richard P; Schwarz, Emilie; McKinley, Paula S et al. (2017) Vagally-mediated heart rate variability and indices of well-being: Results of a nationally representative study. Health Psychol 36:73-81 |
Showing the most recent 10 out of 128 publications
