This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.We will conduct a pilot study that involves the determination of disease specific serum peptide, pretein in patients with colorectal cancer, pancreas cancer using isotope dilution tandem mass spectrometry. Serum samples from 60 subjects (20 patients with metastatic colorectal cancer, 20 patients with locally advanced/or metastatic pancreas cancer, 20 healthy volunteers) will be accrued. Based on the number of eligible subjects seen at the Lombardi Comprehensive Cancer Center per year, patient accrual should be completed after six months. Data analysis will be ongoing and completed by year one.
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