Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will study cognitive and motor dysfunction in patients who are female carriers of ornithine transcarbamylase deficiency (OTCD) or are males with late onset presentation of OTCD. This project seeks to improve our understanding of the underlying neural mechanisms that contribute to metabolic, cognitive, sensory and motor abnormalities in urea cycle disorders. Experimental approaches will combine sensory, cognitive and motor testing with structural, functional and molecular magnetic resonance imaging to study symptomatic and asymptomatic heterozygous female carriers of X-linked Ornithine transcarbamylase deficiency (OTCD), and late onset hemizygous males. Participants will be asked to submit to several tests that include: MRI (magnetic resonance imaging) a non-invasive technique, sensory, cognitive and motor testing and Laboratory testing (blood/urine)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR023942-03
Application #
7951991
Study Section
Special Emphasis Panel (ZRR1-CR-3 (01))
Project Start
2009-04-01
Project End
2010-03-31
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
3
Fiscal Year
2009
Total Cost
$5,180
Indirect Cost

  Institution

Name
Georgetown University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057

  Publications

Goldman, Noreen; Glei, Dana A; Weinstein, Maxine (2018) Declining mental health among disadvantaged Americans. Proc Natl Acad Sci U S A 115:7290-7295
Nersesian, Paula V; Han, Hae-Ra; Yenokyan, Gayane et al. (2018) Loneliness in middle age and biomarkers of systemic inflammation: Findings from Midlife in the United States. Soc Sci Med 209:174-181
Glei, Dana A; Goldman, Noreen; Ryff, Carol D et al. (2018) Physical Function in U.S. Older Adults Compared With Other Populations: A Multinational Study. J Aging Health :898264318759378
Stephan, Yannick; Sutin, Angelina R; Bayard, Sophie et al. (2018) Personality and sleep quality: Evidence from four prospective studies. Health Psychol 37:271-281
Schwartz, Joseph A (2017) Long-term physical health consequences of perceived inequality: Results from a twin comparison design. Soc Sci Med 187:184-192
Bei, Bei; Seeman, Teresa E; Carroll, Judith E et al. (2017) Sleep and Physiological Dysregulation: A Closer Look at Sleep Intraindividual Variability. Sleep 40:
Stepanikova, Irena; Oates, Gabriela R; Bateman, Lori Brand (2017) Does one size fit all? The role of body mass index and waist circumference in systemic inflammation in midlife by race and gender. Ethn Health 22:169-183
Sin, Nancy L; Ong, Anthony D; Stawski, Robert S et al. (2017) Daily positive events and diurnal cortisol rhythms: Examination of between-person differences and within-person variation. Psychoneuroendocrinology 83:91-100
Magidson, Jessica F; Robustelli, Briana L; Seitz-Brown, C J et al. (2017) Activity enjoyment, not frequency, is associated with alcohol-related problems and heavy episodic drinking. Psychol Addict Behav 31:73-78
Boylan, Jennifer Morozink; Robert, Stephanie A (2017) Neighborhood SES is particularly important to the cardiovascular health of low SES individuals. Soc Sci Med 188:60-68

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