Abstract

Objective: To develop a systematic and centralized approach towards our understanding of the impact of acute viral respiratory diseases on selective populations. Specifically, the Acute Viral Respiratory Diseases Unit would: 1. Evaluate the etiology of acute viral respiratory infections in selective populations (eg. infants, asthmatics, elderly, and those with other chronic pulmonary diseases). 2. Assess the pathophysiologic impact of the various respiratory viruses in the above selective populations. 3. Develop improved, rapid diagnostic techniques for viral respiratory infections. 4. Identify and or expand our knowledge on the correlates of immunity associated with protection against disease. 5. Perform clinical trials with promising new vaccines or therapies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI015103-005
Application #
2294992
Study Section
Project Start
1990-12-26
Project End
1995-12-25
Budget Start
1993-01-05
Budget End
1993-12-25
Support Year
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Atmar, Robert L; Piedra, Pedro A; Patel, Shital M et al. (2012) Picornavirus, the most common respiratory virus causing infection among patients of all ages hospitalized with acute respiratory illness. J Clin Microbiol 50:506-8
Beckham, J David; Cadena, Ana; Lin, Jiejian et al. (2005) Respiratory viral infections in patients with chronic, obstructive pulmonary disease. J Infect 50:322-30
Keitel, Wendy A (2002) Repeated immunization of children with inactivated and live attenuated influenza virus vaccines: safety, immunogenicity, and protective efficacy. Semin Pediatr Infect Dis 13:112-9
Couch, R B (2000) Influenza: prospects for control. Ann Intern Med 133:992-8
El-Sahly, H M; Atmar, R L; Glezen, W P et al. (2000) Spectrum of clinical illness in hospitalized patients with ""common cold"" virus infections. Clin Infect Dis 31:96-100
Couch, R B (2000) Prevention and treatment of influenza. N Engl J Med 343:1778-87
Mbawuike, I N; Pacheco, S; Acuna, C L et al. (1999) Mucosal immunity to influenza without IgA: an IgA knockout mouse model. J Immunol 162:2530-7
Atmar, R L; Guy, E; Guntupalli, K K et al. (1998) Respiratory tract viral infections in inner-city asthmatic adults. Arch Intern Med 158:2453-9
Drews, A L; Atmar, R L; Glezen, W P et al. (1997) Dual respiratory virus infections. Clin Infect Dis 25:1421-9
Whimbey, E; Englund, J A; Couch, R B (1997) Community respiratory virus infections in immunocompromised patients with cancer. Am J Med 102:10-8; discussion 25-6

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