Testing Vaccines in Adolescents and Adults

Dolin, Raphael

Abstract

Conduct studies to evaluate respiratory virus vaccines and antivirals, enteric virus vaccines, and selected bacterial vaccines in human populations of different ages and backgrounds. Perform epidemiologic surveillance for infections withthe above agents in the community.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Research and Development Contracts (N01)
• Project #: N01AI052577-007
• Application #: 3594638
• Project Start: 1985-02-01
• Project End: 1989-10-07
• Budget Start: 1987-08-31
• Budget End: 1987-10-07
• Fiscal Year: 1987

Institution

• Name: University of Rochester
• Type: School of Medicine & Dentistry
• DUNS #: 208469486
• City: Rochester
• State: NY
• Country: United States
• Zip Code: 14627

Publications

Dolin, R; Graham, B S; Greenberg, S B et al. (1991) The safety and immunogenicity of a human immunodeficiency virus type 1 (HIV-1) recombinant gp160 candidate vaccine in humans. NIAID AIDS Vaccine Clinical Trials Network. Ann Intern Med 114:119-27

Christy, C; Vosefski, D; Madore, H P (1990) Comparison of three enzyme immunoassays to tissue culture for the diagnosis of rotavirus gastroenteritis in infants and young children. J Clin Microbiol 28:1428-30

Christy, C; Madore, H P; Pichichero, M E et al. (1988) Field trial of rhesus rotavirus vaccine in infants. Pediatr Infect Dis J 7:645-50

Snyder, M H; Betts, R F; DeBorde, D et al. (1988) Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines. J Virol 62:488-95

Treanor, J; Dolin, R; Madore, H P (1988) Production of a monoclonal antibody against the Snow Mountain agent of gastroenteritis by in vitro immunization of murine spleen cells. Proc Natl Acad Sci U S A 85:3613-7

Snyder, M H; Clements, M L; Betts, R F et al. (1986) Evaluation of live avian-human reassortant influenza A H3N2 and H1N1 virus vaccines in seronegative adult volunteers. J Clin Microbiol 23:852-7