This contract will provide a facility for testing malaria vaccines. Three major types of vaccines are being developed currently. One type is designed to protect against the malarial sporozoite which is injected into the bloodstream by the mosquito. The second type will protect against the asexual stages of the parasite which develop in the liver and the red blood cells. A third vaccine type is directed against the sexual stages and will inhibit sexual development in the mosquito thereby preventing transmission. The facility will test vaccines as they become available. Initial testing will involve determination of reactogenicity and immunogenicity. Following establishment of dose parameters, development of immunity will be tested by challenge infections. Various biologic, serologic, immunologic and pathologic methods will be employed during all phases of testing. Data derived from the vaccine testing center will be used as a basis for future studies with the vaccines in field trials.

Project Start
1986-05-25
Project End
1991-05-24
Budget Start
1988-08-31
Budget End
1989-05-24
Support Year
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Davis, J R (1994) Laboratory methods for the conduct of experimental malaria challenge of volunteers. Vaccine 12:321-7
Brown, A E; Herrington, D A; Webster, H K et al. (1992) Urinary neopterin in volunteers experimentally infected with Plasmodium falciparum. Trans R Soc Trop Med Hyg 86:134-6
Beier, M S; Davis, J R; Pumpuni, C B et al. (1992) Ingestion of Plasmodium falciparum sporozoites during transmission by anopheline mosquitoes. Am J Trop Med Hyg 47:195-200
Herrington, D; Davis, J; Nardin, E et al. (1991) Successful immunization of humans with irradiated malaria sporozoites: humoral and cellular responses of the protected individuals. Am J Trop Med Hyg 45:539-47
Hall, R H; Maneval Jr, D R; Collins, J H et al. (1989) Purification and analysis of colonization factor antigen I, coli surface antigen 1, and coli surface antigen 3 fimbriae from enterotoxigenic Escherichia coli. J Bacteriol 171:6372-4
Levine, M M; Herrington, D; Clyde, D et al. (1988) Malaria vaccines: experience with sporozoite vaccines against falciparum malaria. Southeast Asian J Trop Med Public Health 19:369-74