Abstract

The object of this contract is to provide a statistical and data management facility which will serve the entire AIDS Clinical Trials Group system. This facility will produce efficient and timely protocol development; it will assure the quality of all collected data; it will provide disciplined and uniform study monitoring; and will be responsible for prompt and thorough interim and final statistical analyses of all ACTG studies. In addition, the SDAC will provide leadership in statistical science for the development of broad research strategies for HIV infection; it will participate in the setting of scientific and administrative policy for the ACTG; it will develop novel methods of designing and analyzing AIDS clinical trials responsive to the particular needs of the ACTG; and will conduct cross-study analyses of the ACTG database, such as studies of the natural history of HIV or of prognostic factors for disease progression (such as CD4 levels or viral markers).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI095030-011
Application #
2297600
Study Section
Project Start
1989-08-30
Project End
1994-08-29
Budget Start
1992-06-30
Budget End
1993-08-29
Support Year
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Biostatistics & Other Math Sci
Type
Schools of Public Health
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Bebchuk, Judith D; Betensky, Rebecca A (2002) Local likelihood analysis of the latency distribution with interval censored intermediate events. Stat Med 21:3475-91
Rabinowitz, D; Betensky, R A (2000) Approximating the distribution of maximally selected McNemar's statistics. Biometrics 56:897-902
Rabinowitz, D; Betensky, R A; Tsiatis, A A (2000) Using conditional logistic regression to fit proportional odds models to interval censored data. Biometrics 56:511-8
Bebchuk, J D; Betensky, R A (2000) Multiple imputation for simple estimation of the hazard function based on interval censored data. Stat Med 19:405-19
Betensky, R A; Rabinowitz, D (1999) Maximally selected chi2 statistics for k x 2 tables. Biometrics 55:317-20
Betensky, R A; Calvelli, T; Pahwa, S (1999) Predictive value of CD19 measurements for bacterial infections in children infected with human immunodeficiency virus. Clin Diagn Lab Immunol 6:247-53
Betensky, R A (1998) Construction of a continuous stopping boundary from an alpha spending function. Biometrics 54:1061-71
Sperling, R S; Shapiro, D E; McSherry, G D et al. (1998) Safety of the maternal-infant zidovudine regimen utilized in the Pediatric AIDS Clinical Trial Group 076 Study. AIDS 12:1805-13
Weinberg, A; Betensky, R A; Zhang, L et al. (1998) Effect of shipment, storage, anticoagulant, and cell separation on lymphocyte proliferation assays for human immunodeficiency virus-infected patients. Clin Diagn Lab Immunol 5:804-7
Brambilla, D; Leung, S; Lew, J et al. (1998) Absolute copy number and relative change in determinations of human immunodeficiency virus type 1 RNA in plasma: effect of an external standard on kit comparisons. J Clin Microbiol 36:311-4

Showing the most recent 10 out of 30 publications