Abstract

The Prostate, Lung, Colon-rectum and Ovary Cancer Screening Trial (PLCO) is designed to determine in screenees aged 60-74 years at entry whether: a. In females and males (1) screening with flexible sigmoidoscopy (60 cm sigmoidoscope) can reduce mortality from colo-rectal cancer; and, (2) screening with chest x-ray can reduce mortality from lung cancer. b. In males (1) screening with digital rectal examination plus serum prostate-specific antigen (PSA) can reduce mortality from prostate cancer; C. In females (1) screening with pelvic examination plus CA 125 and transvaginal ultrasound can reduce mortality from ovarian cancer; The Contractor shall establish a Study Coordinating and Data Management Center (CC) for the PLCO Cancer Screening Trial to develop and maintain systems and procedures needed for biomedical data management, study coordination, statistical analysis, and report writing. The CC in its coordination efforts acts as a liaison between the Screening Centers, the Central Blood Testing Facility (LAB), study consultants, and the National Cancer Institute Project Officers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Prevention And Control (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CN025476-014
Application #
2357645
Study Section
Project Start
1992-09-30
Project End
2008-09-29
Budget Start
1996-09-25
Budget End
1997-09-29
Support Year
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Westat, Inc.
Department
Type
DUNS #
City
Rockville
State
MD
Country
United States
Zip Code
20850

  Publications

Kang, Xiaozheng; Liu, Hongliang; Onaitis, Mark W et al. (2016) Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls. Carcinogenesis 37:280-289
Pretzel, Shannon M; Andrews, Tara S; Broski, Karen et al. (2015) Participants' Views of Retention Materials Used in the PLCO Cancer Screening Trial. Clin Med Res 13:139-48
Cote, Michele L; Alhajj, Tala; Ruterbusch, Julie J et al. (2015) Risk factors for endometrial cancer in black and white women: a pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2). Cancer Causes Control 26:287-296
Brenner, Darren R; Amos, Christopher I; Brhane, Yonathan et al. (2015) Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia. Carcinogenesis 36:1314-26
Pinsky, Paul F; Gierada, David S; Hocking, William et al. (2014) National Lung Screening Trial findings by age: Medicare-eligible versus under-65 population. Ann Intern Med 161:627-33
Kvale, Paul A; Johnson, Christine Cole; Tammemägi, Martin et al. (2014) Interval lung cancers not detected on screening chest X-rays: How are they different? Lung Cancer 86:41-6
Wang, Yufei; McKay, James D; Rafnar, Thorunn et al. (2014) Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nat Genet 46:736-41
Gierada, David S; Pinsky, Paul; Nath, Hrudaya et al. (2014) Projected outcomes using different nodule sizes to define a positive CT lung cancer screening examination. J Natl Cancer Inst 106:
Patz Jr, Edward F; Pinsky, Paul; Gatsonis, Constantine et al. (2014) Overdiagnosis in low-dose computed tomography screening for lung cancer. JAMA Intern Med 174:269-74
Marcus, Pamela M; Ogden, Sheryl L; Gren, Lisa H et al. (2014) Non-compliance with the initial screening exam visit in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Prev Med 67:82-8

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