Abstract

The primary objective of this project is to clarify the role of HTLV in the etiology of ATL. Secondary objectives center around determination of prevalence of infection in healthy donors, including clustering; determination of prevalence of infection in patients with ATL and in control groups of patients with other malignancies or autoimmune disorders; definition of risk factors through studies on the prevalence of infection in the first degree relatives of HTLV-positive cancer patients, longitudinal studies on infants of HTLV-positive and negative mothers, and studies on HLAtypes on lymphocytes of patients and controls; and determination of the mode of transmission of infection.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CP031006-025
Application #
3627975
Study Section
Project Start
1983-06-15
Project End
Budget Start
1991-06-20
Budget End
1992-09-28
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of the West Indies
Department
Type
DUNS #
City
Kingston
State
Country
Jamaica
Zip Code

  Publications

Goedert, James J; Li, Hong-Chuan; Gao, Xiao-Jiang et al. (2007) Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types. Int J Cancer 121:1092-7
Tseng, Fan-Chen; Brown, Elizabeth E; Maiese, Eric M et al. (2006) Polymorphisms in cytokine genes and risk of Helicobacter pylori infection among Jamaican children. Helicobacter 11:425-30
Maloney, Elizabeth Margaret; Yamano, Yoshihisa; Vanveldhuisen, Paul C et al. (2006) Natural history of viral markers in children infected with human T lymphotropic virus type I in Jamaica. J Infect Dis 194:552-60
Maloney, Elizabeth M; Nagai, Masahiro; Hisada, Michie et al. (2004) Prediagnostic human T lymphotropic virus type I provirus loads were highest in Jamaican children who developed seborrheic dermatitis and severe anemia. J Infect Dis 189:41-5
La Grenade, L; Manns, A; Fletcher, V et al. (1998) Clinical, pathologic, and immunologic features of human T-lymphotrophic virus type I-associated infective dermatitis in children. Arch Dermatol 134:439-44
Wiktor, S Z; Pate, E J; Rosenberg, P S et al. (1997) Mother-to-child transmission of human T-cell lymphotropic virus type I associated with prolonged breast-feeding. J Hum Virol 1:37-44
LaGrenade, L; Sonoda, S; Miller, W et al. (1996) HLA DRB1*DQB1* haplotype in HTLV-I-associated familial infective dermatitis may predict development of HTLV-I-associated myelopathy/tropical spastic paraparesis. Am J Med Genet 61:37-41
White, J D; Johnson, J A; Nam, J M et al. (1996) Distribution of human leukocyte antigens in a population of black patients with human T-cell lymphotrophic virus type I-associated adult T-cell leukemia/lymphoma. Cancer Epidemiol Biomarkers Prev 5:873-7
Kramer, A; Maloney, E M; Morgan, O S et al. (1995) Risk factors and cofactors for human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Jamaica. Am J Epidemiol 142:1212-20
La Grenade, L (1994) HTLV-I, infective dermatitis, and tropical spastic paraparesis. Mol Neurobiol 8:147-53

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