Abstract

The objective of this contract are as follows: 1) determine the prevalence of retrovirus seropositivity in first time blood donors; 2) determine the rate of retrovirus seroconversion in repeat blood donors as a measure of incidence of infection; 3) ascertain risk factors for antibody-positive donors; 4) characterize the blood donor population by geographic location, age, sex, race/ethnicity, and donation history to permit analysis on prevalence, incidence, and risk factors; 5) identify recipients of retrovirus-positive blood units and conduct clinical and laboratory follow-up of these recipients to determine the transmissibility of these agents via transfusion; and 6) establish blood specimen repositories for long-term storage of specimens from study donors and recipients for future testing.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Blood Diseases And Resources (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HB097081-010
Application #
2313359
Study Section
Project Start
1989-07-17
Project End
1998-08-16
Budget Start
1994-09-21
Budget End
1996-08-16
Support Year
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
American National Red Cross Se Michigan
Department
Type
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48232

  Publications

Kleinman, Steven; King, Melissa R; Busch, Michael P et al. (2012) The National Heart, Lung, and Blood Institute retrovirus epidemiology donor studies (Retrovirus Epidemiology Donor Study and Retrovirus Epidemiology Donor Study-II): twenty years of research to advance blood product safety and availability. Transfus Med Rev 26:281-304, 304.e1-2
Schlumpf, Karen S; Glynn, Simone A; Schreiber, George B et al. (2008) Factors influencing donor return. Transfusion 48:264-72
Kleinman, Steven H; Glynn, Simone A; Lee, Tzong-Hae et al. (2007) Prevalence and quantitation of parvovirus B19 DNA levels in blood donors with a sensitive polymerase chain reaction screening assay. Transfusion 47:1756-64
Schreiber, George B; Schlumpf, Karen S; Glynn, Simone A et al. (2006) Convenience, the bane of our existence, and other barriers to donating. Transfusion 46:545-53
Kwaan, Nicholas; Lee, Tzong-Hae; Chafets, Daniel M et al. (2006) Long-term variations in human T lymphotropic virus (HTLV)-I and HTLV-II proviral loads and association with clinical data. J Infect Dis 194:1557-64
Busch, Michael P; Wright, David J; Custer, Brian et al. (2006) West Nile virus infections projected from blood donor screening data, United States, 2003. Emerg Infect Dis 12:395-402
Glynn, Simone A; Schreiber, George B; Murphy, Edward L et al. (2006) Factors influencing the decision to donate: racial and ethnic comparisons. Transfusion 46:980-90
Busch, Michael P; Glynn, Simone A; Stramer, Susan L et al. (2006) Correlates of hepatitis C virus (HCV) RNA negativity among HCV-seropositive blood donors. Transfusion 46:469-75
Roucoux, Diana F; Wang, Baoguang; Smith, Donna et al. (2005) A prospective study of sexual transmission of human T lymphotropic virus (HTLV)-I and HTLV-II. J Infect Dis 191:1490-7
Tobler, L H; Bianco, C; Glynn, S A et al. (2005) Detection of West Nile virus RNA and antibody in frozen plasma components from a voluntary market withdrawal during the 2002 peak epidemic. Transfusion 45:480-6

Showing the most recent 10 out of 48 publications