Abstract

The overall objective of this study is to compare two strategies for the management of atrial fibrillation. The first strategy involves antiarrhythmic drugs to be administered to maintain normal sinus rhythm, if possible. In the second strategy, a different group of drugs and/or catheter ablation will be used for the purpose of heart rate control only. The primary endpoint by which these two strategies will be compared is total mortality. This study will enroll approximately 5,300 patients who will each be randomized to one of the two management strategies. Details of the study design include patient entry criteria, randomization procedures, and analyses which will be incorporated into a protocol developed by the contractor with selected consultants, and the National Heart, Lung, and Blood Institute (NHLBI) staff.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Epidemiology And Clinical Applications (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HC055139-004
Application #
6087741
Study Section
Project Start
1995-03-31
Project End
2002-09-30
Budget Start
1999-06-11
Budget End
2002-09-30
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Statistics and Epidemiology Research Corp
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98105

  Publications

Andrade, Jason G; Roy, Denis; Wyse, D George et al. (2016) Heart rate and adverse outcomes in patients with atrial fibrillation: A combined AFFIRM and AF-CHF substudy. Heart Rhythm 13:54-61
Andrade, Jason G; Roy, Denis; Wyse, D George et al. (2016) ECG Features Associated With Adverse Cardiovascular Outcomes in Patients With Atrial Fibrillation: A Combined AFFIRM and AF-CHF Analysis. J Cardiovasc Electrophysiol 27:404-13
Tremblay-Gravel, Maxime; White, Michel; Roy, Denis et al. (2015) Blood Pressure and Atrial Fibrillation: A Combined AF-CHF and AFFIRM Analysis. J Cardiovasc Electrophysiol 26:509-14
Cadrin-Tourigny, Julia; Wyse, D G; Roy, Denis et al. (2014) Efficacy of amiodarone in patients with atrial fibrillation with and without left ventricular dysfunction: a pooled analysis of AFFIRM and AF-CHF trials. J Cardiovasc Electrophysiol 25:1306-13
Saksena, Sanjeev; Slee, April; Waldo, Albert L et al. (2011) Cardiovascular outcomes in the AFFIRM Trial (Atrial Fibrillation Follow-Up Investigation of Rhythm Management). An assessment of individual antiarrhythmic drug therapies compared with rate control with propensity score-matched analyses. J Am Coll Cardiol 58:1975-85
Kellen, Joyce C; Schron, Eleanor B; Milne, Jill et al. (2006) Perceived effects on patients' health of participation in the atrial fibrillation follow-up investigation of rhythm management study. J Cardiovasc Nurs 21:388-96
Van Gelder, Isabelle C; Wyse, D George; Chandler, Mary L et al. (2006) Does intensity of rate-control influence outcome in atrial fibrillation? An analysis of pooled data from the RACE and AFFIRM studies. Europace 8:935-42
Bush, David; Martin, Lisa W; Leman, Robert et al. (2006) Atrial fibrillation among African Americans, Hispanics and Caucasians: clinical features and outcomes from the AFFIRM trial. J Natl Med Assoc 98:330-9
Raitt, Merritt H; Volgman, Annabelle S; Zoble, Robert G et al. (2006) Prediction of the recurrence of atrial fibrillation after cardioversion in the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study. Am Heart J 151:390-6
DiMarco, John P; Flaker, Gregory; Waldo, Albert L et al. (2005) Factors affecting bleeding risk during anticoagulant therapy in patients with atrial fibrillation: observations from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study. Am Heart J 149:650-6

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