Abstract

This contractor will be the Coordinating Center for the collaborative clinical trial, Cardiac Arrhythmia Treatment Study (CATS). The primary objective of this trial is to see if effective drug treatment of frequent ventricular premature depolarizations in post-myocardial infarction patients will reduce the incidence of sudden cardiac death; secondary objectives are to (1) assess the impact of treatment on all-cause mortality, (2) evaluate adverse drug effects, (3) examine the clinical course of the disease in the control group, and (4) conduct selected substudies to clarify the disease process and the mechanisms of drug efficacy. A three-year recruitment period is designed, following a ten-month planning plase. Follow-up will continue two years beyond patient recruitment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Epidemiology And Clinical Applications (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HC065042-004
Application #
2314014
Study Section
Project Start
1986-08-15
Project End
1995-06-14
Budget Start
1987-09-29
Budget End
1988-04-14
Support Year
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Biostatistics & Other Math Sci
Type
Schools of Public Health
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Hallstrom, Al; Friedman, Lawrence; Denes, Pablo et al. (2003) Do arrhythmia patients improve survival by participating in randomized clinical trials? Observations from the Cardiac Arrhythmia Suppression Trial (CAST)and the Antiarrhythmics Versus Implantable Defibrillators Trial (AVID). Control Clin Trials 24:341-52
Peckova, M; Fahrenbruch, C E; Cobb, L A et al. (1999) Weekly and seasonal variation in the incidence of cardiac arrests. Am Heart J 137:512-5
Every, N R; Hlatky, M A; McDonald, K M et al. (1998) Estimating the proportion of post-myocardial infarction patients who may benefit from prophylactic implantable defibrillator placement from analysis of the CAST registry. Cardiac Arrhythmia Suppression Trial. Am J Cardiol 82:683-5, A8
Peckova, M; Fahrenbruch, C E; Cobb, L A et al. (1998) Circadian variations in the occurrence of cardiac arrests: initial and repeat episodes. Circulation 98:31-9
Hallstrom, A P; Anderson, J L; Carlson, M et al. (1995) Time to arrhythmic, ischemic, and heart failure events: exploratory analyses to elucidate mechanisms of adverse drug effects in the Cardiac Arrhythmia Suppression Trial. Am Heart J 130:71-9
el-Sherif, N; Denes, P; Katz, R et al. (1995) Definition of the best prediction criteria of the time domain signal-averaged electrocardiogram for serious arrhythmic events in the postinfarction period. The Cardiac Arrhythmia Suppression Trial/Signal-Averaged Electrocardiogram (CAST/SAECG) Substudy In J Am Coll Cardiol 25:908-14
Hallstrom, A; Pratt, C M; Greene, H L et al. (1995) Relations between heart failure, ejection fraction, arrhythmia suppression and mortality: analysis of the Cardiac Arrhythmia Suppression Trial. J Am Coll Cardiol 25:1250-7
Reynolds-Haertle, R A; McBride, R (1992) Single vs. double data entry in CAST. Control Clin Trials 13:487-94
Greene, H L; Roden, D M; Katz, R J et al. (1992) The Cardiac Arrhythmia Suppression Trial: first CAST ... then CAST-II. J Am Coll Cardiol 19:894-8
Hallstrom, A P; Verter, J; Friedman, L (1991) Randomizing responders. Cardiac Arrhythmia Suppression Trial (CAST) investigators. Control Clin Trials 12:486-503

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