The primary purpose of this project is to determine the best method of managing women during pregnancy who have hyperphenylalaninemia (HPA) including: classical phenylketonuria (PKU) - blood phenylalanine concentrations of more than 20 mg/dl while on a normal diet; variant PKU - 10-20 mg/dl; or benign HPA - 4-10 mg/dl. Fetal morbidity, with subsequent problems in growth and development, associated with maternal PKU will be assessed in relation to maternal phenylalanine levels.

Project Start
1992-06-23
Project End
1998-06-22
Budget Start
1997-06-23
Budget End
1998-06-22
Support Year
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
Koch, R; Guttler, F; Guldberg, P et al. (1998) Mild hyperphenylalaninemia and heterozygosity of the phenylalanine hydroxylase gene. Mol Genet Metab 63:148-50