Abstract

The primary objective of this contract is to provide for the conduct of an epidemiologic study of the risk of breast cancer among women, ages 40- 64, in relation to oral contraceptive use. Five Field Centers shall participate in the conduct of a multi-center, population-based, concurrent case-control study to elucidate effects of: 1) current and lifetime OC use; 2) timing of OC use relative to other reproductive events; 3) differential effects of contraceptive estrogens and progestins; and 4) possible modification of OC effects by subsequent estrogen or hormone replacement therapy on the risk of breast cancer. A sufficient number of breast cancer cases and controls shall be enlisted to provide for the detection of a small overall relative risk of breast cancer (approximately a 20% increase or decrease) in oral contraceptive users compared to non-users. In addition, the sample size shall be large enough to provide for subgroup analyses, based on possible differences in risk that may exist for various subgroups. Subgroups shall be defined in terms of race, family history of breast cancer, parity and other reproductive characteristics of women, and other suspected breast cancer risk factors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research and Development Contracts (N01)
Project #
N01HD033168-007
Application #
2315137
Study Section
Project Start
1992-11-01
Project End
1999-10-31
Budget Start
1995-09-15
Budget End
1995-10-31
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Emory University
Department
Type
Schools of Public Health
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Ma, Huiyan; Lu, Yani; Malone, Kathleen E et al. (2013) Mortality risk of black women and white women with invasive breast cancer by hormone receptors, HER2, and p53 status. BMC Cancer 13:225
Ma, Huiyan; Lu, Yani; Marchbanks, Polly A et al. (2013) Quantitative measures of estrogen receptor expression in relation to breast cancer-specific mortality risk among white women and black women. Breast Cancer Res 15:R90
Reding, Kerryn W; Chen, Chu; Lowe, Kimberly et al. (2012) Estrogen-related genes and their contribution to racial differences in breast cancer risk. Cancer Causes Control 23:671-81
Reding, Kerryn W; Carlson, Christopher S; Kahsai, Orsalem et al. (2012) Examination of ancestral informative markers and self-reported race with tumor characteristics of breast cancer among Black and White women. Breast Cancer Res Treat 134:801-9
Marchbanks, Polly A; Curtis, Kathryn M; Mandel, Michele G et al. (2012) Oral contraceptive formulation and risk of breast cancer. Contraception 85:342-50
Graber-Naidich, Anna; Gorfine, Malka; Malone, Kathleen E et al. (2011) Missing genetic information in case-control family data with general semi-parametric shared frailty model. Lifetime Data Anal 17:175-94
Dieli-Conwright, Christina M; Sullivan-Halley, Jane; Patel, Alpa et al. (2011) Does hormone therapy counter the beneficial effects of physical activity on breast cancer risk in postmenopausal women? Cancer Causes Control 22:515-22
Lu, Yani; Ma, Huiyan; Malone, Kathleen E et al. (2011) Oral contraceptive use and survival in women with invasive breast cancer. Cancer Epidemiol Biomarkers Prev 20:1391-7
Udler, Miriam S; Ahmed, Shahana; Healey, Catherine S et al. (2010) Fine scale mapping of the breast cancer 16q12 locus. Hum Mol Genet 19:2507-15
Berstad, Paula; Coates, Ralph J; Bernstein, Leslie et al. (2010) A case-control study of body mass index and breast cancer risk in white and African-American women. Cancer Epidemiol Biomarkers Prev 19:1532-44

Showing the most recent 10 out of 35 publications