Abstract

This contract has as its goals the following: 1) to estimate of rate of transmission of HIV infection from infected mother to child, to examine cofactors which may facilitate this transmission, to describe the impact of HIV infection on the outcome of pregnancy (both obstetric and pediatric), and to describe the natural history of HIV infection in children who have vertically transmitted disease. 2) to describe the neurologic and neurodevelopmental impact of HIV infection on children with infection acquired as a result of maternal fetal transmission. This study is being conducted as a prospective, longitudinal follow-up cohort study in 3 centers in New York City. Pregnant women at risk for HIV infection are enrolled, with the infected women serving as index cases and the uninfected, at-risk women as the comparison group. The women are followed throughout pregnancy, and delivery and for four years post-partum together with their children.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research and Development Contracts (N01)
Project #
N01HD082913-006
Application #
2316379
Study Section
Project Start
1988-08-23
Project End
1993-07-31
Budget Start
1990-05-14
Budget End
1990-04-30
Support Year
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Westat, Inc.
Department
Type
DUNS #
City
Rockville
State
MD
Country
United States
Zip Code
20850

  Publications

LaMonte, Ashley C; Paul, Mary E; Read, Jennifer S et al. (2004) Persistent parvovirus B19 infection without the development of chronic anemia in HIV-infected and -uninfected children: the Women and Infants Transmission Study. J Infect Dis 189:847-51
Ioannidis, John P A; Tatsioni, Athina; Abrams, Elaine J et al. (2004) Maternal viral load and rate of disease progression among vertically HIV-1-infected children: an international meta-analysis. AIDS 18:99-108
Read, J S; Tuomala, R; Kpamegan, E et al. (2001) Mode of delivery and postpartum morbidity among HIV-infected women: the women and infants transmission study. J Acquir Immune Defic Syndr 26:236-45
Macmillan, C; Magder, L S; Brouwers, P et al. (2001) Head growth and neurodevelopment of infants born to HIV-1-infected drug-using women. Neurology 57:1402-11
Miller, L S; Atabai, K; Nowakowski, M et al. (2001) Increased expression of CD23 (Fc(epsilon) receptor II) by peripheral blood monocytes of aids patients. AIDS Res Hum Retroviruses 17:443-52
Shifrin, E; Matityahu, D; Feldman, J et al. (2000) Determinants of incident vulvovaginal candidiasis in human immunodeficiency virus-positive women. Infect Dis Obstet Gynecol 8:176-80
Novotna, L; Wilson, T E; Minkoff, H L et al. (1999) Predictors and risk-taking consequences of drug use among HIV-infected women. J Acquir Immune Defic Syndr Hum Retrovirol 20:502-7
Minkoff, H L; Eisenberger-Matityahu, D; Feldman, J et al. (1999) Prevalence and incidence of gynecologic disorders among women infected with human immunodeficiency virus. Am J Obstet Gynecol 180:824-36
Comeau, A M; Pitt, J; Hillyer, G V et al. (1996) Early detection of human immunodeficiency virus on dried blood spot specimens: sensitivity across serial specimens. Women and Infants Transmission Study Group. J Pediatr 129:111-8
Moye Jr, J; Rich, K C; Kalish, L A et al. (1996) Natural history of somatic growth in infants born to women infected by human immunodeficiency virus. Women and Infants Transmission Study Group. J Pediatr 128:58-69

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