Abstract

The purpose of this contract is to develop and carry out a study of the prevalence of human immunodeficiency virus (HIV) antibody in women bearing children in the United States. The contractor will develop the appropriate technologies and assist in the design and execution of this study. This will include assistance in the development and conduct of the necessary laboratory training and quality control procedures for the Regional Testing Laboratories.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research and Development Contracts (N01)
Project #
N01HD082917-009
Application #
2316416
Study Section
Project Start
1988-09-30
Project End
1993-09-29
Budget Start
1992-08-12
Budget End
1992-11-30
Support Year
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Theobald Smith Research Institute, Inc.
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02130

  Publications

Canosa, C A; Grady, G F; Cabello, M L et al. (1997) Anonymous testing of newborn infants for HIV antibodies as a basis for estimating prevalence of HIV in childbearing women: the 1991-1994 study in Spain. Acta Paediatr Suppl 421:67-71
McIntosh, K; Comeau, A M; Wara, D et al. (1996) The utility of IgA antibody to human immunodeficiency virus type 1 in early diagnosis of vertically transmitted infection. National Institute of Allergy and Infectious Diseases and National Institute of Child Health and Human Development Women and Infants Arch Pediatr Adolesc Med 150:598-602
Comeau, A M (1994) Application of the polymerase chain reaction for the detection of HIV in specimens from newborn screening programs. Acta Paediatr Suppl 400:29-30
Grady, G F (1994) HIV mass screening of infants and mothers: historical, technical, and practical issues. Acta Paediatr Suppl 400:39-42
Hsu, H W; Moye Jr, J; Kunches, L et al. (1992) Perinatally acquired human immunodeficiency virus infection: extent of clinical recognition in a population-based cohort. Massachusetts Pediatric HIV Surveillance Working Group. Pediatr Infect Dis J 11:941-5
Comeau, A M; Harris, J A; McIntosh, K et al. (1992) Polymerase chain reaction in detecting HIV infection among seropositive infants: relation to clinical status and age and to results of other assays. J Acquir Immune Defic Syndr 5:271-8
Weiblen, B J; Lee, F K; Cooper, E R et al. (1990) Early diagnosis of HIV infection in infants by detection of IgA HIV antibodies. Lancet 335:988-90
Weiblen, B J; Schumacher, R T; Hoff, R (1990) Detection of IgM and IgA HIV antibodies after removal of IgG with recombinant protein G. J Immunol Methods 126:199-204