Abstract

The overall objective of this program is to conduct a """"""""natural"""""""" history study to characterize the pulmonary and cardiovascular disorders that occur in association with vertically transmitted (mother to child during gestation or during the perinatal time period) human immunodeficiency virus (HIV) infection in children. The study will be coordinated among six geographically separated centers (Baylor College of Medicine, Houston; Children's Hospital/Harvard Medical School, Boston; Mt. Sinai School of Medicine, New York City; Presbyterian Hospital/Columbia University, New York City; UCLA School of Medicine, Los Angeles; and University of California, San Francisco) and the Clinical Coordinating Center (The Cleveland Clinic Foundation). The Program of the Clinical Coordinating Center will include participation in the development of the study protocol, the detailed manual of operations, appropriate data acquisition via distributed data entry, and establishment of suitable data processing procedures. A major activity of the Clinical Coordinating Center will be the development of procedures for control of the quality of the data. A comprehensive program of data management for the Natural History Study will include data review and editing, reduction, display and analysis, and generation of reports and publications.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Lung Diseases (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HR096037-008
Application #
2317423
Study Section
Project Start
1989-05-01
Project End
1995-04-30
Budget Start
1992-03-12
Budget End
1993-04-30
Support Year
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195

  Publications

Fisher, Stacy D; Easley, Kirk A; Orav, E John et al. (2005) Mild dilated cardiomyopathy and increased left ventricular mass predict mortality: the prospective P2C2 HIV Multicenter Study. Am Heart J 150:439-47
Geromanos, Kimberly; Sunkle, Susan N; Mauer, Mary Beth et al. (2004) Successful techniques for retaining a cohort of infants and children born to HIV-infected women: the prospective P2C2 HIV study. J Assoc Nurses AIDS Care 15:48-57
Perez-Atayde, A R; Kearney, D I; Bricker, J T et al. (2004) Cardiac, aortic, and pulmonary arteriopathy in HIV-infected children: the Prospective P2C2 HIV Multicenter Study. Pediatr Dev Pathol 7:61-70
Koumbourlis, Anastassios C; Chen, Xin C; Rao, J Sunil et al. (2004) Maximal expiratory flow at FRC (V'maxFRC): Methods of selection and differences in reported values. Pediatr Pulmonol 37:318-23
Kearney, Debra L; Perez-Atayde, Antonio R; Easley, Kirk A et al. (2003) Postmortem cardiomegaly and echocardiographic measurements of left ventricular size and function in children infected with the human immunodeficiency virus. The Prospective P2C2 HIV Multicenter Study. Cardiovasc Pathol 12:140-8
Rivenes, Shannon M; Colan, Steven D; Easley, Kirk A et al. (2003) Usefulness of the pediatric electrocardiogram in detecting left ventricular hypertrophy: results from the Prospective Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2 HIV) multicenter study. Am Heart J 145:716-23
Lipshultz, Steven E; Easley, Kirk A; Orav, E John et al. (2002) Cardiovascular status of infants and children of women infected with HIV-1 (P(2)C(2) HIV): a cohort study. Lancet 360:368-73
Starc, Thomas J; Lipshultz, Steven E; Easley, Kirk A et al. (2002) Incidence of cardiac abnormalities in children with human immunodeficiency virus infection: The prospective P2C2 HIV study. J Pediatr 141:327-34
Lipshultz, S E; Easley, K A; Orav, E J et al. (2001) Reliability of multicenter pediatric echocardiographic measurements of left ventricular structure and function: the prospective P(2)C(2) HIV study. Circulation 104:310-6
Norton, K I; Kattan, M; Rao, J S et al. (2001) Chronic radiographic lung changes in children with vertically transmitted HIV-1 infection. AJR Am J Roentgenol 176:1553-8

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