This proposal is for the participation in a nationwide collaborative study to determine the prevalence and natural history of pulmonary and cardiac complications associated with HIV infection in utero, in infancy and in early childhood. Using a common protocol with other centers we will evaluate in a longitudinal fashion the types, incidence, course and outcome of pulmonary and cardiac disorders in infants and children who are infected with HIV or who are at great risk for infection by the perinatal route. This longitudinal study will be available to all infants and children in Los Angeles County. We have designated two major centers for children (UCLA Medical Center and children's Hospital of Los Angeles) as the coordinating institutions. Full cooperation has been assured by the Southern California Pediatrics AIDS Clinical Trial Group (Yvonne J. Bryson, M.D., Principal Investigator NIH-NIAID-88-AI-03). This consortium will be associated with the already existing UCLA and USC ATEU's and share facilities and personnel. Through a network of study coordinators, study nurses, and support personnel, patients born or followed at the centers are enrolled for national cooperative studies within our own units. Appropriate arrangements for patient care and socio-economic counselling and support will be established. Using this integrated patient network, longitudinal studies of pulmonary and cardiac disorders will be done.

Agency
National Institute of Health (NIH)
Institute
Division of Lung Diseases (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HR096038-006
Application #
2317439
Study Section
Project Start
1989-05-22
Project End
1995-05-21
Budget Start
1991-06-21
Budget End
1992-02-14
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Pediatrics
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Fisher, Stacy D; Easley, Kirk A; Orav, E John et al. (2005) Mild dilated cardiomyopathy and increased left ventricular mass predict mortality: the prospective P2C2 HIV Multicenter Study. Am Heart J 150:439-47
Geromanos, Kimberly; Sunkle, Susan N; Mauer, Mary Beth et al. (2004) Successful techniques for retaining a cohort of infants and children born to HIV-infected women: the prospective P2C2 HIV study. J Assoc Nurses AIDS Care 15:48-57
Perez-Atayde, A R; Kearney, D I; Bricker, J T et al. (2004) Cardiac, aortic, and pulmonary arteriopathy in HIV-infected children: the Prospective P2C2 HIV Multicenter Study. Pediatr Dev Pathol 7:61-70
Koumbourlis, Anastassios C; Chen, Xin C; Rao, J Sunil et al. (2004) Maximal expiratory flow at FRC (V'maxFRC): Methods of selection and differences in reported values. Pediatr Pulmonol 37:318-23
Kearney, Debra L; Perez-Atayde, Antonio R; Easley, Kirk A et al. (2003) Postmortem cardiomegaly and echocardiographic measurements of left ventricular size and function in children infected with the human immunodeficiency virus. The Prospective P2C2 HIV Multicenter Study. Cardiovasc Pathol 12:140-8
Rivenes, Shannon M; Colan, Steven D; Easley, Kirk A et al. (2003) Usefulness of the pediatric electrocardiogram in detecting left ventricular hypertrophy: results from the Prospective Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2 HIV) multicenter study. Am Heart J 145:716-23
Lipshultz, Steven E; Easley, Kirk A; Orav, E John et al. (2002) Cardiovascular status of infants and children of women infected with HIV-1 (P(2)C(2) HIV): a cohort study. Lancet 360:368-73
Starc, Thomas J; Lipshultz, Steven E; Easley, Kirk A et al. (2002) Incidence of cardiac abnormalities in children with human immunodeficiency virus infection: The prospective P2C2 HIV study. J Pediatr 141:327-34
Colin, A A; Sunil Rao, J; Chen, X C et al. (2001) Forced expiratory flow in uninfected infants and children born to HIV-infected mothers. Am J Respir Crit Care Med 163:865-73
Chinen, J; Easley, K A; Mendez, H et al. (2001) Decline of CD3-positive T-cell counts by 6 months of age is associated with rapid disease progression in HIV-1--infected infants. J Allergy Clin Immunol 108:265-8

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