The Department of Pediatric at Baylor College of Medicine (BCM) and University of Texas Medical School at Houston (UT) intend jointly to become a National Heart, Lung, and Blood Institute (NHLBI)-funded evaluation unit for the lung and cardiac complications of pediatric HIV infection with UT as the subcontractor; the Departments of Obstetrics (OB) and BCM and UT and the Department of Pathology at BCM will also participate. These operations will be accomplished by use of centralized BCM facilities located at Texas Children's Hospital -- Clinical Research Center (CRC). The NHLBI proposal will interact with several National Institutes of Health (NIH)- funded pediatric AIDS research protocols, either active or pending, which utilize the CRC and which involve both BCM and UT in a similar contractor-subcontractor relationship. The present NHLBI proposal will utilize OB departments at BCM and UT which will insure that every infant born to a high-risk mother (intravenous drug abuser, carrier of sexually- transmitted diseases, carrier of hepatitis B) in the city of Houston will be enrolled. In addition to infants at risk for HIV infection entering the NHLBI project through the OB intake system, children already identified with HIV infection, some of which will be on NIH treatment protocols, will be available for entry into the NHLBI study. Crucial for the assessment of clinical measurements of lung and heart function is the tissue correlation provided by the Department of Pathology, both biopsy and autopsy examinations. Equally important is the correlation between clinical measurements of lung and heart function and the presence of intercurrent or secondary viral infection, as will be provided by surveillance viral cultures and the use of viral gene probes. Also, simultaneous immunologic measurements of T lymphocyte subsets, lymphocyte proliferation to mitogens and antigens, interleukin-2 production, and soluble interleukin-2 receptor production will add other important corregulatory dimensions. A single data entry and management system will facilitate exchange of information between investigators at BCM and UT and the NHLBI.

National Institute of Health (NIH)
Division of Lung Diseases (NHLBI)
Research and Development Contracts (N01)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Baylor College of Medicine
Schools of Medicine
United States
Zip Code
Fisher, Stacy D; Easley, Kirk A; Orav, E John et al. (2005) Mild dilated cardiomyopathy and increased left ventricular mass predict mortality: the prospective P2C2 HIV Multicenter Study. Am Heart J 150:439-47
Geromanos, Kimberly; Sunkle, Susan N; Mauer, Mary Beth et al. (2004) Successful techniques for retaining a cohort of infants and children born to HIV-infected women: the prospective P2C2 HIV study. J Assoc Nurses AIDS Care 15:48-57
Perez-Atayde, A R; Kearney, D I; Bricker, J T et al. (2004) Cardiac, aortic, and pulmonary arteriopathy in HIV-infected children: the Prospective P2C2 HIV Multicenter Study. Pediatr Dev Pathol 7:61-70
Koumbourlis, Anastassios C; Chen, Xin C; Rao, J Sunil et al. (2004) Maximal expiratory flow at FRC (V'maxFRC): Methods of selection and differences in reported values. Pediatr Pulmonol 37:318-23
Kearney, Debra L; Perez-Atayde, Antonio R; Easley, Kirk A et al. (2003) Postmortem cardiomegaly and echocardiographic measurements of left ventricular size and function in children infected with the human immunodeficiency virus. The Prospective P2C2 HIV Multicenter Study. Cardiovasc Pathol 12:140-8
Rivenes, Shannon M; Colan, Steven D; Easley, Kirk A et al. (2003) Usefulness of the pediatric electrocardiogram in detecting left ventricular hypertrophy: results from the Prospective Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2 HIV) multicenter study. Am Heart J 145:716-23
Starc, Thomas J; Lipshultz, Steven E; Easley, Kirk A et al. (2002) Incidence of cardiac abnormalities in children with human immunodeficiency virus infection: The prospective P2C2 HIV study. J Pediatr 141:327-34
Lipshultz, Steven E; Easley, Kirk A; Orav, E John et al. (2002) Cardiovascular status of infants and children of women infected with HIV-1 (P(2)C(2) HIV): a cohort study. Lancet 360:368-73
Colin, A A; Sunil Rao, J; Chen, X C et al. (2001) Forced expiratory flow in uninfected infants and children born to HIV-infected mothers. Am J Respir Crit Care Med 163:865-73
Chinen, J; Easley, K A; Mendez, H et al. (2001) Decline of CD3-positive T-cell counts by 6 months of age is associated with rapid disease progression in HIV-1--infected infants. J Allergy Clin Immunol 108:265-8

Showing the most recent 10 out of 19 publications