The primary objective of the program is to further understand HIV infection in infants and children and its effects on disorders of the heart and lung. To this end we will: 1. collect information on the prenatal course and subsequent pulmonary cardiac growth, development and function of Group I: Infants and children with recently diagnosed, perinatally transmitted symptomatic HIV infection; Newborn infants of mothers infected with HIV; Newborn infants of mothers who are seronegative for HIV infection but at high risk of infection for HIV 2. determine the types, incidence, course, and outcome of pulmonary and Cardiovascular disorders in these children and to elucidate the etiology and pathophysiology of these lung and heart abnormalities. The program is separated into three scopes: 1. Clinical and Laboratory - To recruit the required number of patients; coordinate clinical care with various studies outlined in this proposal and to provide core laboratory support for infectious and immunological components of this investigation. 2. Cardiology - To determine the natural history of cardiac disease in children with HIV infection and the incidence of both primary and secondary cardiac disease in children with perinatal HIV infection; identify early clinical marker of cardiac disease in infected children; determine laboratory markers and co-factors which precipitate clinical disease in infected patients. 3. Pulmonary - To study the natural history of pulmonary disorders in infants and children infected with HIV transmitted either in utero or during the perinatal period; collect information on the relationship between HIV infection and subsequent pulmonary growth, development and function; study the role of viruses; to identify tests that might aid in early diagnosis and treatment.

Agency
National Institute of Health (NIH)
Institute
Division of Lung Diseases (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HR096043-000
Application #
2317500
Study Section
Project Start
1989-05-22
Project End
1995-05-21
Budget Start
1989-05-22
Budget End
1990-05-21
Support Year
Fiscal Year
1989
Total Cost
Indirect Cost
Name
New York-Presbyterian Hospital
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10032
Fisher, Stacy D; Easley, Kirk A; Orav, E John et al. (2005) Mild dilated cardiomyopathy and increased left ventricular mass predict mortality: the prospective P2C2 HIV Multicenter Study. Am Heart J 150:439-47
Geromanos, Kimberly; Sunkle, Susan N; Mauer, Mary Beth et al. (2004) Successful techniques for retaining a cohort of infants and children born to HIV-infected women: the prospective P2C2 HIV study. J Assoc Nurses AIDS Care 15:48-57
Perez-Atayde, A R; Kearney, D I; Bricker, J T et al. (2004) Cardiac, aortic, and pulmonary arteriopathy in HIV-infected children: the Prospective P2C2 HIV Multicenter Study. Pediatr Dev Pathol 7:61-70
Koumbourlis, Anastassios C; Chen, Xin C; Rao, J Sunil et al. (2004) Maximal expiratory flow at FRC (V'maxFRC): Methods of selection and differences in reported values. Pediatr Pulmonol 37:318-23
Kearney, Debra L; Perez-Atayde, Antonio R; Easley, Kirk A et al. (2003) Postmortem cardiomegaly and echocardiographic measurements of left ventricular size and function in children infected with the human immunodeficiency virus. The Prospective P2C2 HIV Multicenter Study. Cardiovasc Pathol 12:140-8
Rivenes, Shannon M; Colan, Steven D; Easley, Kirk A et al. (2003) Usefulness of the pediatric electrocardiogram in detecting left ventricular hypertrophy: results from the Prospective Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2 HIV) multicenter study. Am Heart J 145:716-23
Lipshultz, Steven E; Easley, Kirk A; Orav, E John et al. (2002) Cardiovascular status of infants and children of women infected with HIV-1 (P(2)C(2) HIV): a cohort study. Lancet 360:368-73
Starc, Thomas J; Lipshultz, Steven E; Easley, Kirk A et al. (2002) Incidence of cardiac abnormalities in children with human immunodeficiency virus infection: The prospective P2C2 HIV study. J Pediatr 141:327-34
Meyers, A; Shah, A; Cleveland, R H et al. (2001) Thymic size on chest radiograph and rapid disease progression in human immunodeficiency virus 1-infected children. Pediatr Infect Dis J 20:1112-8
Colin, A A; Sunil Rao, J; Chen, X C et al. (2001) Forced expiratory flow in uninfected infants and children born to HIV-infected mothers. Am J Respir Crit Care Med 163:865-73

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