Abstract

The specific objectives of this contract are to establish the validity of current documentation of observed early initial response to treatment of acute ischemic stroke with recombinant tissue plasminogen activator (rt-PA) and to establish time limits for delivering such treatment. The objectives will be accomplished by completing a Phase II-B randomized controlled clinical study of RT-PA for acute ischemic stroke.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research and Development Contracts (N01)
Project #
N01NS002373-012
Application #
2321139
Study Section
Project Start
1990-06-30
Project End
1995-10-31
Budget Start
1994-11-01
Budget End
1995-10-31
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Henry Ford Health System
Department
Neurology
Type
Schools of Medicine
DUNS #
073134603
City
Detroit
State
MI
Country
United States
Zip Code
48202

  Publications

Rhoney, Denise H; Coplin, William M; Lin, Yan et al. (2010) Time of day, outcome, and response to thrombolytic therapy: the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Trial experience. J Stroke Cerebrovasc Dis 19:40-8
Nichols, Christopher; Khoury, Jane; Brott, Thomas et al. (2008) Intravenous recombinant tissue plasminogen activator improves arterial recanalization rates and reduces infarct volumes in patients with hyperdense artery sign on baseline computed tomography. J Stroke Cerebrovasc Dis 17:64-8
Jauch, Edward C; Lindsell, Christopher; Broderick, Joseph et al. (2006) Association of serial biochemical markers with acute ischemic stroke: the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator Stroke Study. Stroke 37:2508-13
Tanne, David; Macko, Richard F; Lin, Yan et al. (2006) Hemostatic activation and outcome after recombinant tissue plasminogen activator therapy for acute ischemic stroke. Stroke 37:1798-804
Hacke, Werner; Donnan, Geoffrey; Fieschi, Cesare et al. (2004) Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 363:768-74
Tanne, D; Levine, S R; Brey, R L et al. (2003) Antiphospholipid-protein antibodies and acute ischemic stroke in the NINDS rt-PA Stroke Trial. Neurology 61:1158-9
Bruno, A; Levine, S R; Frankel, M R et al. (2002) Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial. Neurology 59:669-74
Broderick, Joseph P; Hacke, Werner (2002) Treatment of acute ischemic stroke: Part I: recanalization strategies. Circulation 106:1563-9
Lu, M; Tilley, B C; NINDS t-PA Stroke Trial Study Group (2001) Use of odds ratio or relative risk to measure a treatment effect in clinical trials with multiple correlated binary outcomes: data from the NINDS t-PA stroke trial. Stat Med 20:1891-901
Lyden, P; Lu, M; Kwiatkowski, T et al. (2001) Thrombolysis in patients with transient neurologic deficits. Neurology 57:2125-8

Showing the most recent 10 out of 13 publications