Abstract

The Women's Health Initiative is a randomized controlled clinical trial conducted in 40 clinical centers across the United States addressing some of the most common causes of death, disability, and impaired quality of life in postmenopausal women ages 50-79: cardiovascular disease; breast and colon cancer; and osteoporosis. The three components of this disease prevention trial are: (1) hormone replacement therapy with a primary outcomes of coronary heart disease and stroke and secondary outcomes of hip and other fractures; (2) low fat dietary intervention with primary outcomes of breast cancer and colorectal cancer and a secondary outcome of coronary heart disease; and (3) calcium and vitamin D supplementation with a primary outcome of hip fractures and secondary outcomes of colorectal cancer and combined fractures. A concurrent observational study will provide estimates of health effects of known risk factors and new predictors for disease. Each clinical center will collect data through questionnaires and biological specimens over 8-12 years.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Women'S Health Initiative - Office of The Director Nih (WH)
Type
Research and Development Contracts (N01)
Project #
N01WH032120-016
Application #
6347043
Study Section
Project Start
1993-04-30
Project End
2005-09-14
Budget Start
2000-08-28
Budget End
2001-09-30
Support Year
Fiscal Year
2000
Total Cost
$755,545
Indirect Cost

  Institution

Name
University of California San Diego
Department
Family Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Culbertson, Vaughn L; Rahman, Shaikh E; Bosen, Grayson C et al. (2018) Implications of Off-Target Serotoninergic Drug Activity: An Analysis of Serotonin Syndrome Reports Using a Systematic Bioinformatics Approach. Pharmacotherapy 38:888-898
Kirwa, Kipruto; Eliot, Melissa N; Wang, Yi et al. (2014) Residential proximity to major roadways and prevalent hypertension among postmenopausal women: results from the Women's Health Initiative San Diego Cohort. J Am Heart Assoc 3:e000727
Gorodeski, Eiran Z; Ishwaran, Hemant; Kogalur, Udaya B et al. (2011) Use of hundreds of electrocardiographic biomarkers for prediction of mortality in postmenopausal women: the Women's Health Initiative. Circ Cardiovasc Qual Outcomes 4:521-32
Kripke, Daniel F; Langer, Robert D; Elliott, Jeffrey A et al. (2011) Mortality related to actigraphic long and short sleep. Sleep Med 12:28-33
Allison, Matthew A; Manson, Joann E; Aragaki, Aaron et al. (2010) Vasomotor symptoms and coronary artery calcium in postmenopausal women. Menopause 17:1136-45
Li, Rongling; O'Sullivan, Mary J; Robinson, Jennifer et al. (2009) Family history of myocardial infarction predicts incident coronary heart disease in postmenopausal women with diabetes: the Women's Health Initiative Observational Study. Diabetes Metab Res Rev 25:725-32
Allison, Matthew A; Manson, Joann E; Langer, Robert D et al. (2008) Oophorectomy, hormone therapy, and subclinical coronary artery disease in women with hysterectomy: the Women's Health Initiative coronary artery calcium study. Menopause 15:639-47
Langer, Robert D; Pradhan, Aruna D; Lewis, Cora E et al. (2005) Baseline associations between postmenopausal hormone therapy and inflammatory, haemostatic, and lipid biomarkers of coronary heart disease. The Women's Health Initiative Observational Study. Thromb Haemost 93:1108-16
Phillips, Lawrence S; Langer, Robert D (2005) Postmenopausal hormone therapy: critical reappraisal and a unified hypothesis. Fertil Steril 83:558-66
Hsia, Judith; Aragaki, Aaron; Bloch, Michael et al. (2004) Predictors of angina pectoris versus myocardial infarction from the Women's Health Initiative Observational Study. Am J Cardiol 93:673-8

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