Build field-based clinical research capacity on malaria at field sites in Africa to conduct clinical trials of candidate malaria vaccines or other potential malaria prevention and intervention strategies. Activities include: ? Establish well-characterized cohorts for future P. faliciparum vaccine trials; ? Collect data on the incidence of P. falciparum infection, uncomplicated malaria, severe malaria, and malaria mortality;and ? Initiate assessment of the host immune responses that are associated with a decreased incidence of these outcomes.
