The primary goal of this Program Project Grant is to determine the effect of chronic heavy alcohol use on the systemic, CNS and PNS morbidity of HIV disease. Chronic heavy alcohol use may hasten systemic HIV disease progression (either via biological effects of via effects on treatment seeking and treatment adherence) resulting in increased CNS & PNS morbidity, or it may have direct effects on the CNS & PNS independent of systemic HIV disease progression. Both mechanisms and their effects will be evaluated in a two year longitudinal of HIV+ and HIV- chronic heavy drinkers and light/non drinkers. In support of these efforts, the core will serve five major functions. . The Core will provide the administrative oversight and support of the Program. . The Core will be responsible for screening and recruiting all subjects for the PPG, for scheduling and coordinating all subject assessments, for handing subject payments, for dealing with interactions with subjects' physicians and treatment facilities, and for tracking subjects and for calling them back for assessments at 6, 12, 18 and 24 months. . The Core will be responsible for virologic/immunologic assessments, assessment of the status of subjects' HIV disease and HIV disease treatment, drinking history, family density of drinking problems, nutritional status, risk behavior, treatment seeking behavior, treatment adherence, quality of life, and neuropsychological function. . The Core will be responsible for a CSF substudy comparing viral load and anti-viral drug levels in CSF versus blood. . The Core will be responsible for data management and design and coordination of statistical analyses across the PPG.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Program Projects (P01)
Project #
3P01AA011493-02S1
Application #
6327544
Study Section
Project Start
2000-07-10
Project End
2000-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
2
Fiscal Year
2000
Total Cost
$254,615
Indirect Cost
Name
Northern California Institute Research & Education
Department
Type
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94121
Cardenas, Valerie A; Durazzo, Timothy C; Gazdzinski, Stefan et al. (2011) Brain morphology at entry into treatment for alcohol dependence is related to relapse propensity. Biol Psychiatry 70:561-7
Van Boven, Robert W; Harrington, Greg S; Hackney, David B et al. (2009) Advances in neuroimaging of traumatic brain injury and posttraumatic stress disorder. J Rehabil Res Dev 46:717-57
Pa, Judy; Boxer, Adam; Chao, Linda L et al. (2009) Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment. Ann Neurol 65:414-23
Cardenas, V A; Meyerhoff, D J; Studholme, C et al. (2009) Evidence for ongoing brain injury in human immunodeficiency virus-positive patients treated with antiretroviral therapy. J Neurovirol 15:324-33
Studholme, Colin (2008) Dense feature deformation morphometry: Incorporating DTI data into conventional MRI morphometry. Med Image Anal 12:742-51
Gazdzinski, Stefan; Durazzo, Timothy C; Weiner, Michael W et al. (2008) Are treated alcoholics representative of the entire population with alcohol use disorders? A magnetic resonance study of brain injury. Alcohol 42:67-76
Gazdzinski, Stefan; Kornak, John; Weiner, Michael W et al. (2008) Body mass index and magnetic resonance markers of brain integrity in adults. Ann Neurol 63:652-7
Durazzo, Timothy C; Cardenas, Valerie A; Studholme, Colin et al. (2007) Non-treatment-seeking heavy drinkers: effects of chronic cigarette smoking on brain structure. Drug Alcohol Depend 87:76-82
Durazzo, Timothy C; Gazdzinski, Stefan; Meyerhoff, Dieter J (2007) The neurobiological and neurocognitive consequences of chronic cigarette smoking in alcohol use disorders. Alcohol Alcohol 42:174-85
Studholme, Colin (2007) Incorporating DTI data as a constraint in deformation tensor morphometry between T1 MR images. Inf Process Med Imaging 20:223-32

Showing the most recent 10 out of 23 publications