Alcohol use contributes to morbidity and mortality associated with HIV in numerous ways including (a) reducing antiretroviral medication adherence and efficacy, (b) contributing to worse virologic outcomes and immune functioning, (c) exacerbating liver dysfunction and hepatitis co-infection, and (d) exacerbating neurocognitive deficits associated with HIV. In addition, alcohol use among both HIV-infected and uninfected individuals is implicated in high-risk sexual behavior that leads to HIV transmission. Given multiple pathways through which alcohol impacts HIV morbidity, mortality and transmission, we propose an integrated, multifaceted, interdisciplinary approach to forward science on alcohol/HIV interactions and inform clinical approaches to caring for people living with HIV and efforts to prevent HIV transmission, both nationally and internationally. The overall aim of this Comprehensive Alcohol Research Center (CARC) is to conduct and disseminate multidisciplinary state-of-the-art research on biobehavioral interactions between alcohol and HIV and on interventions to reduce alcohol use among HIV-infected patients and individuals at high risk for HIV transmission. The CARC has 9 integrated parts: an Administrative Core , four Research Components, two Scientific Cores (Virology and Biostatistics), a Pilot Projects Component, and an Education/Dissemination Component that serves as a national resource for training and dissemination. Research activities address overlapping hypotheses regarding key variables (alcohol use, virology, hepatic function, neurocognitive function, use of antiretroviral therapy, and high-risk sexual behavior) and interrelationships among these variables using diverse methodologies (both animal and human research) and populations. These activities provide an integrated body of innovative alcohol/HIV research that can yield far greater total public health impact than any or all of them could if conducted independently. Further, this CARC will serve as the nexus for integration of alcohol/HIV science across proposed components, innovative pilot projects, complementary studies, and with other NIAAA Centers, yielding new insights into interactions between alcohol and HIV and into interventions to reduce drinking among those with HIV and others at risk for transmission.

Public Health Relevance

By increasing understanding of how excessive alcohol consumption and interventions to reduce excessive drinking can impact HIV-related outcomes, this Comprehensive Alcohol Research Center on HIV/AIDS can contribute greatly to efforts to improve the health of those living with HIV and to reduce the spread of HIV.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Program Projects (P01)
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Study Section
Special Emphasis Panel (ZAA1-DD (90))
Program Officer
Roach, Deidra
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Brown University
Public Health & Prev Medicine
Schools of Public Health
United States
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Nunn, Amy; Parker, Sharon; McCoy, Katryna et al. (2018) African American Clergy Perspectives About the HIV Care Continuum: Results From a Qualitative Study in Jackson, Mississippi. Ethn Dis 28:85-92
Cohen, Ronald A; Siegel, S; Gullett, J M et al. (2018) Neural response to working memory demand predicts neurocognitive deficits in HIV. J Neurovirol 24:291-304
Laws, M Barton; Magill, Molly; Mastroleo, Nadine R et al. (2018) A sequential analysis of motivational interviewing technical skills and client responses. J Subst Abuse Treat 92:27-34
Barry, Declan T; Marshall, Brandon D L; Becker, William C et al. (2018) Duration of opioid prescriptions predicts incident nonmedical use of prescription opioids among U.S. veterans receiving medical care. Drug Alcohol Depend 191:348-354
Kahler, Christopher W; Pantalone, David W; Mastroleo, Nadine R et al. (2018) Motivational interviewing with personalized feedback to reduce alcohol use in HIV-infected men who have sex with men: A randomized controlled trial. J Consult Clin Psychol 86:645-656
Pérez, Ashley E; Wray, Tyler B; Celio, Mark A et al. (2018) HIV-related thought avoidance, sexual risk, and alcohol use among men who have sex with men. AIDS Care 30:930-935
Wray, Tyler B; Adia, Alexander C; Pérez, Ashley E et al. (2018) Timeline: A web application for assessing the timing and details of health behaviors. Am J Drug Alcohol Abuse :1-10
Wray, Tyler B; Chan, Philip A; Celio, Mark A et al. (2018) HIV Testing Among Men Who Have Sex with Men in the Northeastern United States. AIDS Behav 22:531-537
Sileo, Katelyn M; Kintu, Michael; Kiene, Susan M (2018) The intersection of intimate partner violence and HIV risk among women engaging in transactional sex in Ugandan fishing villages. AIDS Care 30:444-452
Gullett, Joseph M; Lamb, Damon G; Porges, Eric et al. (2018) The Impact of Alcohol Use on Frontal White Matter in HIV. Alcohol Clin Exp Res 42:1640-1649

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