Abstract

This is a program project including an integrated series of basic science and clinical investigations into the cell biology and physiology of aging. Cell biology studies include materials from aging rodents and man and focus on 1) the relation of aging and ultraviolet light to changes in cell growth in vitro, 2) the influence of age on capacity of the cell to serve as host for herpes virus infection, and 3) the influence of age on smooth muscle cell proliferation in the arterial wall after injury. The clinical physiologic studies include investigations of the effect of age on 1) the metabolism and secretion of arginine vasopressin, 2) the inter-relation of the sympathetic nervous system and carbohydrate tolerance, and 3) the inter-relation between salt balance and prostaglandin physiology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG000599-11
Application #
3090543
Study Section
Aging Review Committee (AGE)
Project Start
1977-07-01
Project End
1991-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
11
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Elahi, Dariush; Ruff, Dennis A; Carlson, Olga D et al. (2016) Does GLP-1 suppress its own basal secretion? Endocr Res 41:16-20
Elahi, Dariush; Angeli, Franca S; Vakilipour, Amin et al. (2014) GLP-1(32-36)amide, a novel pentapeptide cleavage product of GLP-1, modulates whole body glucose metabolism in dogs. Peptides 59:20-4
Ahmed, Sofia B; Bentley-Lewis, Rhonda; Hollenberg, Norman K et al. (2009) A comparison of prediction equations for estimating glomerular filtration rate in pregnancy. Hypertens Pregnancy 28:243-55
Abu-Hamdah, Rania; Rabiee, Atoosa; Meneilly, Graydon S et al. (2009) Clinical review: The extrapancreatic effects of glucagon-like peptide-1 and related peptides. J Clin Endocrinol Metab 94:1843-52
Moore, T J; Rich, G; McKnight, J A et al. (1996) Salt sensitivity of hypertension and responses to angiotensin converting enzyme inhibition with benazepril. Am J Hypertens 9:54-60
Hollenberg, N K; Moore, T J (1994) Age and the renal blood supply: renal vascular responses to angiotensin converting enzyme inhibition in healthy humans. J Am Geriatr Soc 42:805-8
Allan, D R; McKnight, J A; Kifor, I et al. (1994) Converting enzyme inhibition and renal tissue angiotensin II in the rat. Hypertension 24:516-22
Bauer, K A; Kass, B L; ten Cate, H et al. (1990) Factor IX is activated in vivo by the tissue factor mechanism. Blood 76:731-6
Lee, J K; Gordon, P R; Stall, G M et al. (1989) Phenolic and tyrosyl ring iodothyronine deiodination by the Caco-2 human colon carcinoma cell line. Metabolism 38:1154-61
Bauer, K A; Weiss, L M; Sparrow, D et al. (1987) Aging-associated changes in indices of thrombin generation and protein C activation in humans. Normative Aging Study. J Clin Invest 80:1527-34