This application seeks renewed support for a Program Project which, since 1977, has been the scientific cornerstone for the growth of a productive academic program in gerontology at Beth Israel Hospital and Harvard Medical School. The present proposal continues our prior focus on elucidation of the physiologic mechanism of normal aging in the absence of disease and extends this physiologic approach to prevalent and morbid illnesses of the elderly. The proposed closely inter-related projects build on substantial preliminary data from our laboratories and include: 1) Outcomes of extracellular volume change: the oldest old; 2) Nutrition and aging: Protein and energy interactions; and 3) Sodium sensitivity of hypertension and aging. Data resulting from these investigations promise to advance our knowledge in important clinical aspects of physiologic changes with age. The shared resources and scientific collaborations in this renewal are more extensive than in previous applications with four Clinical Research Centers, a subject recruiting team, and substantial blending of senior investigative gerontologic expertise among the proposed projects. the Program Project forms an excellent substrate for training of gerontologic investigators, particularly from the physician scientist trainees entering our Institutional Physician Scientist Program, and graduates of the Division on Aging Fellowship Program entering our Geriatric Research Training Center.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
Project #
Application #
Study Section
Biological and Clinical Aging Review Committee (BCA)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Beth Israel Deaconess Medical Center
United States
Zip Code
Elahi, Dariush; Ruff, Dennis A; Carlson, Olga D et al. (2016) Does GLP-1 suppress its own basal secretion? Endocr Res 41:16-20
Elahi, Dariush; Angeli, Franca S; Vakilipour, Amin et al. (2014) GLP-1(32-36)amide, a novel pentapeptide cleavage product of GLP-1, modulates whole body glucose metabolism in dogs. Peptides 59:20-4
Ahmed, Sofia B; Bentley-Lewis, Rhonda; Hollenberg, Norman K et al. (2009) A comparison of prediction equations for estimating glomerular filtration rate in pregnancy. Hypertens Pregnancy 28:243-55
Abu-Hamdah, Rania; Rabiee, Atoosa; Meneilly, Graydon S et al. (2009) Clinical review: The extrapancreatic effects of glucagon-like peptide-1 and related peptides. J Clin Endocrinol Metab 94:1843-52
Moore, T J; Rich, G; McKnight, J A et al. (1996) Salt sensitivity of hypertension and responses to angiotensin converting enzyme inhibition with benazepril. Am J Hypertens 9:54-60
Hollenberg, N K; Moore, T J (1994) Age and the renal blood supply: renal vascular responses to angiotensin converting enzyme inhibition in healthy humans. J Am Geriatr Soc 42:805-8
Allan, D R; McKnight, J A; Kifor, I et al. (1994) Converting enzyme inhibition and renal tissue angiotensin II in the rat. Hypertension 24:516-22
Bauer, K A; Kass, B L; ten Cate, H et al. (1990) Factor IX is activated in vivo by the tissue factor mechanism. Blood 76:731-6
Lee, J K; Gordon, P R; Stall, G M et al. (1989) Phenolic and tyrosyl ring iodothyronine deiodination by the Caco-2 human colon carcinoma cell line. Metabolism 38:1154-61
Bauer, K A; Weiss, L M; Sparrow, D et al. (1987) Aging-associated changes in indices of thrombin generation and protein C activation in humans. Normative Aging Study. J Clin Invest 80:1527-34