Abstract

This program entitled """"""""DNA Transactions and Aging"""""""" consists of an interrelated set of six projects directed by Drs. Paul Berg, Ronald W. Davis, David S. Hogness, Dale Kaiser, Arthur Kornberg and Robert Lehman. The program focuses on DNA transactions that we think are relevant to aging because they either cause or prevent alterations in a cell's repertoire of genetic functions. The rate at which such genetic errors accumulate in cell populations is clearly important to any consideration of the aging problem and, of course, that rate is determined by the interplay between these causative and preventive transactions. The program encompasses two areas of concentration within this central theme. One of these concerns the transposable DNA elements that move about the genome and generate mutational rearrangements in the chromosomal DNA. The other concerns those transactions that repair damage to the chromosomal DNA and regulate the fidelity of DNA replication.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG002908-08
Application #
3090632
Study Section
Aging Review Committee (AGE)
Project Start
1986-08-01
Project End
1991-07-31
Budget Start
1988-08-01
Budget End
1989-07-31
Support Year
8
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Satoh, M S; Hanawalt, P C (1997) Competent transcription initiation by RNA polymerase II in cell-free extracts from xeroderma pigmentosum groups B and D in an optimized RNA transcription assay. Biochim Biophys Acta 1354:241-51
Satoh, M S; Hanawalt, P C (1996) TFIIH-mediated nucleotide excision repair and initiation of mRNA transcription in an optimized cell-free DNA repair and RNA transcription assay. Nucleic Acids Res 24:3576-82
Elias-Arnanz, M; Firmenich, A A; Berg, P (1996) Saccharomyces cerevisiae mutants defective in plasmid-chromosome recombination. Mol Gen Genet 252:530-8
Koehler, D R; Courcelle, J; Hanawalt, P C (1996) Kinetics of pyrimidine(6-4)pyrimidone photoproduct repair in Escherichia coli. J Bacteriol 178:1347-50
Dutch, R E; Bianchi, V; Lehman, I R (1995) Herpes simplex virus type 1 DNA replication is specifically required for high-frequency homologous recombination between repeated sequences. J Virol 69:3084-9
Lommel, L; Carswell-Crumpton, C; Hanawalt, P C (1995) Preferential repair of the transcribed DNA strand in the dihydrofolate reductase gene throughout the cell cycle in UV-irradiated human cells. Mutat Res 336:181-92
Hanawalt, P C (1995) DNA repair comes of age. Mutat Res 336:101-13
Hays, S L; Firmenich, A A; Berg, P (1995) Complex formation in yeast double-strand break repair: participation of Rad51, Rad52, Rad55, and Rad57 proteins. Proc Natl Acad Sci U S A 92:6925-9
Firmenich, A A; Elias-Arnanz, M; Berg, P (1995) A novel allele of Saccharomyces cerevisiae RFA1 that is deficient in recombination and repair and suppressible by RAD52. Mol Cell Biol 15:1620-31
Ford, J M; Lommel, L; Hanawalt, P C (1994) Preferential repair of ultraviolet light-induced DNA damage in the transcribed strand of the human p53 gene. Mol Carcinog 10:105-9

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