Abstract

Activities subsumed under the Core support the whole program. They include: -- The Clinical Dementia Service, which provides carefully evaluated clinical material for study, both patients and tissues including autopsy brain; -- Provision of biopsy brain (""""""""neurosurgical waste"""""""") tissue; -- Provision of tissue cultures; -- Computer and statistical support; -- Consultations, including an annual external review; -- Administration services.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG003853-06
Application #
3817746
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Burke Rehabilitation Center (White Plns,NY)
Department
Type
DUNS #
City
White Plains
State
NY
Country
United States
Zip Code
10605

  Publications

Ko, L W; Sheu, K F; Thaler, H T et al. (2001) Selective loss of KGDHC-enriched neurons in Alzheimer temporal cortex: does mitochondrial variation contribute to selective vulnerability? J Mol Neurosci 17:361-9
Nolan, K A; Lino, M M; Seligmann, A W et al. (1998) Absence of vascular dementia in an autopsy series from a dementia clinic. J Am Geriatr Soc 46:597-604
Bernstein, J J; Karp, S M; Goldberg, W J et al. (1996) Human leptomeningeal-derived cells express GFAP and HLADR when grafted into rat spinal cord. Int J Dev Neurosci 14:681-7
Calingasan, N Y; Bernstein, J J; Blass, J P (1996) Absence of neuronal and glial proteins in human and rat leptomeninges in situ. J Neurol Sci 144:21-3
Makar, T K; Cooper, A J; Tofel-Grehl, B et al. (1995) Carnitine, carnitine acetyltransferase, and glutathione in Alzheimer brain. Neurochem Res 20:705-11
Black, R S; DeGiorgio, L A; Sheu, K F et al. (1994) Expression of neuronal proteins in cells from normal adult rat brain propagated in serial culture. J Neurochem 62:2132-40
DeGiorgio, L A; Sheu, K F; Blass, J P (1994) Culture from human leptomeninges of cells containing neurofilament protein and neuron-specific enolase. J Neurol Sci 124:141-8
Blass, J P; Markesbery, W R; Ko, L W et al. (1994) Presence of neuronal proteins in serially cultured cells from autopsy human brain. J Neurol Sci 121:132-8
Huang, H M; Martins, R; Gandy, S et al. (1994) Use of cultured fibroblasts in elucidating the pathophysiology and diagnosis of Alzheimer's disease. Ann N Y Acad Sci 747:225-44
Sheu, K F; Cooper, A J; Koike, K et al. (1994) Abnormality of the alpha-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease. Ann Neurol 35:312-8

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