""""""""Age-associated memory impairment"""""""" (AAMI), the term adopted by a recent NIMH workgroup to refer to the memory problems associated with normal aging, currently includes apparent memory impairment due to inattention, reduced processing capacity, or other factors that can limit memory, as well as genuine memory impairment due to impairment in specific memory processes. Cued recall with controlled learning has shown that some aged with AAMI have genuine memory deficits shown by decreased recall in spite of effective processing while others who have impaired memory on uncontrolled tests have preserved memory when induced to process effectively. The long term objective is to refine and validate the construct of AAMI by prospective longitudinal study of aged adults by using cued recall with controlled learning to identify genuine memory impairment or preserved memory. A battery of cognitive tests will be administered 3 times during a 5 year follow-up period. Multivariate analyses of the data will address the following specific aims: (1) to test the hypothesis that adults with AAMI who have genuine memory deficits do not develop dementia; (2) to test the hypothesis that adults with AAMI who have preserved memory do not develop genuine memory impairment; (3) to provide construct validation of the measurement of genuine memory impairment and preservation of memory; (4) to identify patterns of cognitive dysfunctions in aged with preservation of memory and in aged with genuine memory impairment; and (5) to elucidate the relationship between memory complaints and objective measures of memory. The results should improve the diagnosis and treatment of AAMI. If those aged with genuine memory impairment do not develop dementia, this will distinguish AAMI from dementia. If those with genuine memory impairment do develop dementia, then such genuine memory impairment would be an early indicator of dementia. If those aged with preserved memory continue to have preserved memory, it would indicate that AAMI is not due to aging alone, but may be due to other time-related factors that may be preventable or treatable. The identification of genuine memory impairment should also facilitate the selection of patients for the pharmacologic testing and treatment of patients with AAMI.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG003949-09
Application #
3809042
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Hill, Nikki L; Mogle, Jacqueline (2018) Alzheimer's disease risk factors as mediators of subjective memory impairment and objective memory decline: protocol for a construct-level replication analysis. BMC Geriatr 18:260
Eurelings, Lisa Sm; van Dalen, Jan Willem; Ter Riet, Gerben et al. (2018) Apathy and depressive symptoms in older people and incident myocardial infarction, stroke, and mortality: a systematic review and meta-analysis of individual participant data. Clin Epidemiol 10:363-379
Scott, Stacey B; Sliwinski, Martin J; Zawadzki, Matthew et al. (2018) A Coordinated Analysis of Variance in Affect in Daily Life. Assessment :1073191118799460
Blumen, Helena M; Brown, Lucy L; Habeck, Christian et al. (2018) Gray matter volume covariance patterns associated with gait speed in older adults: a multi-cohort MRI study. Brain Imaging Behav :
Kidana, Kiwami; Tatebe, Takuya; Ito, Kaori et al. (2018) Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice. EMBO Mol Med 10:
Sanchez-Contreras, Monica Y; Kouri, Naomi; Cook, Casey N et al. (2018) Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci. Mol Neurodegener 13:37
Kasanuki, Koji; Ross, Owen A; DeTure, Michael A et al. (2018) Relationships between lewy and tau pathologies in 375 consecutive non-Alzheimer's olfactory bulbs. Mov Disord 33:333-334
Ogaki, Kotaro; Martens, Yuka A; Heckman, Michael G et al. (2018) Multiple system atrophy and apolipoprotein E. Mov Disord 33:647-650
Hyun, Jinshil; Sliwinski, Martin J; Almeida, David M et al. (2018) The moderating effects of aging and cognitive abilities on the association between work stress and negative affect. Aging Ment Health 22:611-618
Fleysher, Roman; Lipton, Michael L; Noskin, Olga et al. (2018) White matter structural integrity and transcranial Doppler blood flow pulsatility in normal aging. Magn Reson Imaging 47:97-102

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