Abstract

The overall goal of this project is to combine longitudinal and cross sectional methodologies to identify markers of cognitive decline in normally aging and dementing individuals. In addition to the longitudinal data on changes in temporal and spatial aspects of event-related potentials (ERPs), specific experiments will assess cognitive operations that are vulnerable in the elderly and those at risk for dementia: semantic activation, elaboration at encoding on memory tasks, and motor slowing. Event-related potentials (ERPs) will be recorded from the scalp, time locked to auditory and visual stimuli. The ERP waveform is expected to vary as a function of experimental condition, age, and cognitive impairment, thus providing measures of the timing and efficiency of cognitive processing in three groups of the aged: normal, high risk for dementia, and demented. A detailed scalp topographic analysis, utilizing the Laplacian method for reference free measurements of transcranial current flow, will provide an indication of age-related change in the differential intracranial generation of these ERP components.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG003949-12
Application #
3767942
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine
Department
Type
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Fleysher, Roman; Lipton, Michael L; Noskin, Olga et al. (2018) White matter structural integrity and transcranial Doppler blood flow pulsatility in normal aging. Magn Reson Imaging 47:97-102
Sliwinski, Martin J; Mogle, Jacqueline A; Hyun, Jinshil et al. (2018) Reliability and Validity of Ambulatory Cognitive Assessments. Assessment 25:14-30
Zammit, Andrea R; Robitaille, Annie; Piccinin, Andrea et al. (2018) Associations between aging-related changes in grip strength and cognitive function in older adults: A systematic review. J Gerontol A Biol Sci Med Sci :
Graham-Engeland, Jennifer E; Sin, Nancy L; Smyth, Joshua M et al. (2018) Negative and positive affect as predictors of inflammation: Timing matters. Brain Behav Immun 74:222-230
Hyun, Jinshil; Sliwinski, Martin J; Smyth, Joshua M (2018) Waking Up on the Wrong Side of the Bed: The Effects of Stress Anticipation on Working Memory in Daily Life. J Gerontol B Psychol Sci Soc Sci :
Li, Zeran; Del-Aguila, Jorge L; Dube, Umber et al. (2018) Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure. Genome Med 10:43
Majd, Marzieh; Graham-Engeland, Jennifer E; Smyth, Joshua M et al. (2018) Distinct inflammatory response patterns are evident among men and women with higher depressive symptoms. Physiol Behav 184:108-115
Bond, Dale S; Thomas, J Graham; Lipton, Richard B et al. (2018) Behavioral Weight Loss Intervention for Migraine: A Randomized Controlled Trial. Obesity (Silver Spring) 26:81-87
Zammit, Andrea R; Hall, Charles B; Katz, Mindy J et al. (2018) Class-Specific Incidence of All-Cause Dementia and Alzheimer's Disease: A Latent Class Approach. J Alzheimers Dis 66:347-357
Sun, Wenyan; Samimi, Hanie; Gamez, Maria et al. (2018) Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies. Nat Neurosci 21:1038-1048

Showing the most recent 10 out of 319 publications