Clinical studies have suggested that over 80% of cases of dementia in subjects over age 85 are due to Alzheimer's disease (AD), but clinicopathologic studies which assess the etiology of dementia in the oldest-old (subjects over 85) as well as the pathology of cognitively normal elderly are lacking. Over the past decade, we have performed prospective clinicopathological studies on over 86 elderly subjects who had been assessed with yearly neuropsychological testing. Our data suggest that a majority of cases of dementia in the oldest-old are not due to AD. In this renewal application, we propose to continue our clinicopathologic studies to describe the neuropathology of normal elderly and to determine the pathologic substrate of dementia in the oldest-old. We will utilize the expanded population in the clinical core, and estimate that we will be able to complete an additional 85 clinicopathologic studies by 1997. To test the hypothesis that dementia is associated with synapse loss and white matter pathology we will perform quantitative measures of synapse- associated proteins and galactolipids in standardized sections of cortex and white matter. We will then measure the association of these pathological variables with clinical measures such as memory test scores and VIQ. Because sensitivity and specificity of diagnosis of dementia subtype is poor in elderly subjects, we will analyze our autopsy proven cases to determine which clinical signs or pattern of scores on standard and experimental neuropsychological tests will improve diagnostic accuracy. We will test the hypothesis that cardiac ischemia is associated with ischemic dementias by performing 24 hour ambulatory EKGs in controls and subjects with different types of dementia.
| Ogaki, Kotaro; Martens, Yuka A; Heckman, Michael G et al. (2018) Multiple system atrophy and apolipoprotein E. Mov Disord 33:647-650 |
| Hyun, Jinshil; Sliwinski, Martin J; Almeida, David M et al. (2018) The moderating effects of aging and cognitive abilities on the association between work stress and negative affect. Aging Ment Health 22:611-618 |
| Fleysher, Roman; Lipton, Michael L; Noskin, Olga et al. (2018) White matter structural integrity and transcranial Doppler blood flow pulsatility in normal aging. Magn Reson Imaging 47:97-102 |
| Sliwinski, Martin J; Mogle, Jacqueline A; Hyun, Jinshil et al. (2018) Reliability and Validity of Ambulatory Cognitive Assessments. Assessment 25:14-30 |
| Zammit, Andrea R; Robitaille, Annie; Piccinin, Andrea et al. (2018) Associations between aging-related changes in grip strength and cognitive function in older adults: A systematic review. J Gerontol A Biol Sci Med Sci : |
| Graham-Engeland, Jennifer E; Sin, Nancy L; Smyth, Joshua M et al. (2018) Negative and positive affect as predictors of inflammation: Timing matters. Brain Behav Immun 74:222-230 |
| Hyun, Jinshil; Sliwinski, Martin J; Smyth, Joshua M (2018) Waking Up on the Wrong Side of the Bed: The Effects of Stress Anticipation on Working Memory in Daily Life. J Gerontol B Psychol Sci Soc Sci : |
| Li, Zeran; Del-Aguila, Jorge L; Dube, Umber et al. (2018) Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure. Genome Med 10:43 |
| Majd, Marzieh; Graham-Engeland, Jennifer E; Smyth, Joshua M et al. (2018) Distinct inflammatory response patterns are evident among men and women with higher depressive symptoms. Physiol Behav 184:108-115 |
| Bond, Dale S; Thomas, J Graham; Lipton, Richard B et al. (2018) Behavioral Weight Loss Intervention for Migraine: A Randomized Controlled Trial. Obesity (Silver Spring) 26:81-87 |
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