With an established population of elderly subjects with strictly defined mild senile dementia/Alzheimer type (SDAT) and matched healthy elderly controls, we are continuing the longitudinal investigation of the interrelationships and predictive value of clinical, behavioral and multiple biomedical factors. Serial assessments include detailed clinical examinations, psychometric test battery, advanced quantitative CT, EEG, study of event-related potentials (ERP), positron emission tomography (PET), and assay of plasma levels of S-100 protein, a biochemical marker of impaired glial cell integrity. Having found significant differences between mild SDAT subjects and controls on some of these measures, we are starting a prospective study on elderly subjects with cognitive impairment too mild to be diagnosed as SDAT. These subjects and matched controls will be studied by the same measures given above, with the goal of identifying interrelationships and factors which predict the development of SDAT. At a single assessment we will study subjects with mild, moderate and severe SDAT by clinical, psychometric, CT, EEG, and ERP measures. We will compare results from a """"""""cross-sectional"""""""" assessment with those of the longitudinal study. The PET study will describe local cerebral hemodynamics and metabolism in healthy aging and SDAT to explore PET's role in diagnosis and prognosis. Further, it may provide evidence for the role, if and, of brain circulation in pathogenesis of SDAT. We will assess all subjects serially with measures of behavior (activities of daily living, functional capacities) for comparison with our other studies. The longitudinal impact of SDAT on the primary caregiver will also be assessed. The possible relationship between susceptibility to SDAT and HLA antigen frequencies will be examined by HLA study of all subjects. Subjects will be followed until autopsy when results of pathologic examination of the brain will be compared with previous data. Remaining brain tissue will be frozen and stored. These studies have bearing on the enormous national health problem o senile dementia and on the important adaptive capabilities of the healthy elderly.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG003991-02
Application #
3090774
Study Section
Aging Review Committee (AGE)
Project Start
1984-01-01
Project End
1988-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Blaiotta, Claudia; Freund, Patrick; Cardoso, M Jorge et al. (2018) Generative diffeomorphic modelling of large MRI data sets for probabilistic template construction. Neuroimage 166:117-134
Schindler, Suzanne E; Sutphen, Courtney L; Teunissen, Charlotte et al. (2018) Upward drift in cerebrospinal fluid amyloid ? 42 assay values for more than 10 years. Alzheimers Dement 14:62-70
Gabel, Matthew; Gooblar, Jonathan; Roe, Catherine M et al. (2018) Political Ideology, Confidence in Science, and Participation in Alzheimer Disease Research Studies. Alzheimer Dis Assoc Disord 32:179-184
Blue, Elizabeth E; Bis, Joshua C; Dorschner, Michael O et al. (2018) Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project. Dement Geriatr Cogn Disord 45:1-17
Roe, Catherine M; Babulal, Ganesh M; Mishra, Shruti et al. (2018) Tau and Amyloid Positron Emission Tomography Imaging Predict Driving Performance Among Older Adults with and without Preclinical Alzheimer's Disease. J Alzheimers Dis 61:509-513
Rao, Shuquan; Ghani, Mahdi; Guo, Zhiyun et al. (2018) An APOE-independent cis-eSNP on chromosome 19q13.32 influences tau levels and late-onset Alzheimer's disease risk. Neurobiol Aging 66:178.e1-178.e8
Laurido-Soto, Osvaldo; Brier, Matthew R; Simon, Laura E et al. (2018) Patient characteristics and outcome associations in AMPA receptor encephalitis. J Neurol :
Peloso, Gina M; van der Lee, Sven J; International Genomics of Alzheimer's Project (IGAP) et al. (2018) Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease. Alzheimers Dement (Amst) 10:595-598
Sato, Chihiro; Barthélemy, Nicolas R; Mawuenyega, Kwasi G et al. (2018) Tau Kinetics in Neurons and the Human Central Nervous System. Neuron 98:861-864
Armstrong, Richard A; McKee, Ann C; Stein, Thor D et al. (2018) Cortical degeneration in chronic traumatic encephalopathy and Alzheimer's disease neuropathologic change. Neurol Sci :

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