This application is for the 5-year renewal of the program project, Healthy Aging and Senile Dementia (HASD), now in its 19th year. In this renewal there is a continued focus on the clinical, psychometric, and neuropathologic correlates of DAT in comparison with healthy aging with a new thrust addressing preclinical Alzheimer's disease. Six interactive and supportive Cores are proposed: Core A: Clinical recruits, enrolls, and clinically assesses subjects annually to supply all projects; Core B: Psychometrics provides longitudinal cognitive assessments of subjects; Core C: Neuropathology performs postmortem examinations for clinicopathological correlation for all studies and provides appropriate tissue and data to Projects 2 and 4; Core D: Biostatistics oversees data management and provides statistical input to all Cores and projects; and Core E: Administration provides administrative support to all components and assures progress in accomplishing program project goals. Core F: Neuroimaging is a new core to collect structural imaging data on our cohort to visualize change in anatomy associated with cognitive decline. Two new projects replace the current Projects 1 and 2 which are being absorbed by appropriate cores. The new Project 1 (""""""""Dementia Assessment in the Community"""""""" JC Morris) evaluates a modified version of our informant-based research assessment in two community settings. The new Project 2 (""""""""Novel Biomarkers to predict Alzheimer disease"""""""" DM Holtzman) examines potential novel biomarkers (Abeta40/Abeta42 ratio, CSF sulfatides) and other variables to predict presence and progression of AD. Two current projects continue in new directions. Prelect 3 (""""""""Attention Profiles in Healthy Aging and Early Stage DAT,"""""""" D Balota) will explore the subcomponents of attention as early indicators of DAT and individual attentional profiles in both variability in performance, and personality characteristics. Project 4 (""""""""Predicting Cognitive Decline in Healthy Elders,"""""""" JG Csernansky) evaluates the ability of sensitive neuroimaging measures to discriminate aging and very mild DAT. Together, these projects and their supporting cores will define very mild DAT in comparison with healthy brain aging and address the issue of detecting preclinical disease.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG003991-24
Application #
7172973
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5 (M1))
Program Officer
Buckholtz, Neil
Project Start
1984-01-01
Project End
2008-12-31
Budget Start
2007-03-01
Budget End
2007-12-31
Support Year
24
Fiscal Year
2007
Total Cost
$1,872,829
Indirect Cost
Name
Washington University
Department
Neurology
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Roe, Catherine M; Babulal, Ganesh M; Mishra, Shruti et al. (2018) Tau and Amyloid Positron Emission Tomography Imaging Predict Driving Performance Among Older Adults with and without Preclinical Alzheimer's Disease. J Alzheimers Dis 61:509-513
Rao, Shuquan; Ghani, Mahdi; Guo, Zhiyun et al. (2018) An APOE-independent cis-eSNP on chromosome 19q13.32 influences tau levels and late-onset Alzheimer's disease risk. Neurobiol Aging 66:178.e1-178.e8
Laurido-Soto, Osvaldo; Brier, Matthew R; Simon, Laura E et al. (2018) Patient characteristics and outcome associations in AMPA receptor encephalitis. J Neurol :
Peloso, Gina M; van der Lee, Sven J; International Genomics of Alzheimer's Project (IGAP) et al. (2018) Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease. Alzheimers Dement (Amst) 10:595-598
Armstrong, Richard A; McKee, Ann C; Stein, Thor D et al. (2018) Cortical degeneration in chronic traumatic encephalopathy and Alzheimer's disease neuropathologic change. Neurol Sci :
Sato, Chihiro; Barthélemy, Nicolas R; Mawuenyega, Kwasi G et al. (2018) Tau Kinetics in Neurons and the Human Central Nervous System. Neuron 98:861-864
Deming, Yuetiva; Li, Zeran; Benitez, Bruno A et al. (2018) Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease? Expert Opin Ther Targets 22:587-598
Millar, Peter R; Balota, David A; Bishara, Anthony J et al. (2018) Multinomial models reveal deficits of two distinct controlled retrieval processes in aging and very mild Alzheimer disease. Mem Cognit 46:1058-1075
Musiek, Erik S; Bhimasani, Meghana; Zangrilli, Margaret A et al. (2018) Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease. JAMA Neurol 75:582-590
Vlassenko, Andrei G; Gordon, Brian A; Goyal, Manu S et al. (2018) Aerobic glycolysis and tau deposition in preclinical Alzheimer's disease. Neurobiol Aging 67:95-98

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