This project will address the need for a practical and valid assessment method which can be used by community physicians to enhance the recognition and diagnosis of dementia. The assessment method entitled the """"""""Brief Instrument for Dementia Detection (BIDD)"""""""" to be used in this project will contain specific items identified from our current longitudinal research studies which are determined to best discriminate dementia from nondemented aging. These items will be combined into a brief clinical assessment tool for use by practicing physicians. The long-term objective is to validate that successful informant-based research clinical assessment procedures can be adapted to improve detection of dementia in the community. Currently, dementia is underdiagnosed in the community. Community physicians overwhelming request the availability of clear, time efficient assessment protocols to aid the recognition of dementia. Specifically: 1. This project will develop a sensitive, portable dementia assessment instrument from key items derived from a collateral source-based research dementia protocol. 2. Health care professionals will be trained about dementia, dementia therapy, and the administration and interpretation of the brief assessment tool called BIDD through the newly established Urban Partner's Program. 3. The BIDD will be refined and tested for cultural sensitivity in a pilot study using a population-based sample enrolled in the """"""""Physical frailty in urban African Americans"""""""". 4. Evaluate the efficacy of the BIDD in detecting dementia in older adults (75 years old or older) by studying the change from baseline in the frequency of dementia diagnosis and treatment in St. Louis County Health Center patients and the increased request for dementia services from the Alzheimers Association. Also validity of the BIDD will studied by evaluating a randomly selected subset of Health Center patients and the population-based research subject sample with our research dementia assessment protocol to yield a """"""""gold standard"""""""" diagnosis of dementia for comparison with the BIDD-derived diagnosis.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG003991-24
Application #
7365128
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2007-01-01
Budget End
2007-12-31
Support Year
24
Fiscal Year
2007
Total Cost
$110,674
Indirect Cost
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
La Joie, Renaud; Bejanin, Alexandre; Fagan, Anne M et al. (2018) Associations between [18F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample. Neurology 90:e282-e290
Roe, Catherine M; Babulal, Ganesh M; Stout, Sarah H et al. (2018) Using the A/T/N Framework to Examine Driving in Preclinical AD. Geriatrics (Basel) 3:
Swarup, Vivek; Hinz, Flora I; Rexach, Jessica E et al. (2018) Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia. Nat Med :
Suárez-Calvet, Marc; Capell, Anja; Araque Caballero, Miguel Ángel et al. (2018) CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. EMBO Mol Med 10:
Bussy, Aurélie; Snider, B Joy; Coble, Dean et al. (2018) Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network. Neurobiol Aging 75:42-50
Besser, Lilah; Kukull, Walter; Knopman, David S et al. (2018) Version 3 of the National Alzheimer's Coordinating Center's Uniform Data Set. Alzheimer Dis Assoc Disord 32:351-358
Su, Yi; Flores, Shaney; Hornbeck, Russ C et al. (2018) Utilizing the Centiloid scale in cross-sectional and longitudinal PiB PET studies. Neuroimage Clin 19:406-416
Kawamura, Naoki; Yokota, Tatsuya; Hontani, Hidekata (2018) Super-Resolution of Magnetic Resonance Images via Convex Optimization with Local and Global Prior Regularization and Spectrum Fitting. Int J Biomed Imaging 2018:9262847
Cruchaga, Carlos; Del-Aguila, Jorge L; Saef, Benjamin et al. (2018) Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms. Alzheimers Dement 14:205-214
Maxwell, Taylor J; Corcoran, Chris; Del-Aguila, Jorge L et al. (2018) Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels. Alzheimers Res Ther 10:86

Showing the most recent 10 out of 911 publications