Abstract

The applicant proposes to study the effects of age and stress on catecholamine metabolism and hypothalamic peptide concentrations. He proposes to measure (1) hypothalamic amine biosynthesis and peptide (in particular LHRH, oxytocin, somatostatin, vasopressin, thyrotropin releasing hormone and enkephalins) content in rats of different ages using an in vitro methodology which he has developed and used previously for other studies; (2) the effect of acute and chronic stress on these parameters; (3) the efficacy of opioid agonists on this system in animals of various age with and without stress; and (4) effects of pharmacological intervention on stress and aging changes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG004207-03
Application #
3960162
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Wake Forest University Health Sciences
Department
Type
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106

  Publications

Landfield, P W; Eldridge, J C (1991) The glucocorticoid hypothesis of brain aging and neurodegeneration: recent modifications. Acta Endocrinol (Copenh) 125 Suppl 1:54-64
Kerr, D S; Campbell, L W; Applegate, M D et al. (1991) Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging. J Neurosci 11:1316-24
O'Steen, W K; Brodish, A (1990) Scleral calcification and photoreceptor cell death during aging and exposure to chronic stress. Am J Anat 189:62-8
Odio, M; Brodish, A (1989) Age-related adaptation of pituitary-adrenocortical responses to stress. Neuroendocrinology 49:382-8
Brodish, A; Odio, M (1989) Age-dependent effects of chronic stress on ACTH and corticosterone responses to an acute novel stress. Neuroendocrinology 49:496-501
Odio, M R; Brodish, A (1988) Effects of age on metabolic responses to acute and chronic stress. Am J Physiol 254:E617-24
MacLean, D B; Eldridge, J C; Brodish, A (1988) Substance P and somatostatin content and transport in the vagus and sciatic nerves of the aging Fischer 344 rat. Neurobiol Aging 9:273-7
Sonntag, W E; Goliszek, A G; Brodish, A et al. (1987) Diminished diurnal secretion of adrenocorticotropin (ACTH), but not corticosterone, in old male rats: possible relation to increased adrenal sensitivity to ACTH in vivo. Endocrinology 120:2308-15
Odio, M; Brodish, A; Ricardo Jr, M J (1987) Effects on immune responses by chronic stress are modulated by aging. Brain Behav Immun 1:204-15
O'Steen, W K; Sweatt, A J; Brodish, A (1987) Effects of acute and chronic stress on the neural retina of young, mid-age, and aged Fischer-344 rats. Brain Res 426:37-46

Showing the most recent 10 out of 18 publications