Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
3P01AG004220-11S1
Application #
6295315
Study Section
Project Start
1999-04-15
Project End
1999-05-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
11
Fiscal Year
1999
Total Cost
Indirect Cost
Name
New York St Off of Mr and Dev Disab
Department
Type
DUNS #
City
Albany
State
NY
Country
United States
Zip Code
12229
Frackowiak, Janusz; Sukontasup, Thirasak; Potempska, Anna et al. (2004) Lysosomal deposition of Abeta in cultures of brain vascular smooth muscle cells is enhanced by iron. Brain Res 1002:67-75
Mazur-Kolecka, Bozena; Frackowiak, Janusz; Le Vine 3rd, Harry et al. (2003) TGFbeta1 enhances formation of cellular Abeta/apoE deposits in vascular myocytes. Neurobiol Aging 24:355-64
Frackowiak, Janusz; Miller, David L; Potempska, Anna et al. (2003) Secretion and accumulation of Abeta by brain vascular smooth muscle cells from AbetaPP-Swedish transgenic mice. J Neuropathol Exp Neurol 62:685-96
Mazur-Kolecka, Bozena; Frackowiak, Janusz; Kowal, Dagmar et al. (2002) Oxidative protein damage in cells engaged in beta-amyloidosis is related to apoE genotype. Neuroreport 13:465-8
Frackowiak, J; Mazur-Kolecka, B; Kaczmarski, W et al. (2001) Deposition of Alzheimer's vascular amyloid-beta is associated with decreased expression of brain L-3-hydroxyacyl-coenzyme A dehydrogenase (ERAB). Brain Res 907:44-53
Yang, S Y; He, X Y (2001) Role of type 10 17beta-hydroxysteroid dehydrogenase in the pathogenesis of Alzheimer's disease. Adv Exp Med Biol 487:101-10
Dolzhanskaya, N; Conti, J; Schwenk, V et al. (2001) Self-cleaving-ribozyme-mediated reduction of betaAPP in human rhabdomyosarcoma cells. Arch Biochem Biophys 387:223-32
Johnsingh, A A; Johnston, J M; Merz, G et al. (2000) Altered binding of mutated presenilin with cytoskeleton-interacting proteins. FEBS Lett 465:53-8
Bobinski, M; de Leon, M J; Wegiel, J et al. (2000) The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer's disease. Neuroscience 95:721-5
Wisniewski, H M; Wegiel, J; Vorbrodt, A W et al. (2000) Role of perivascular cells and myocytes in vascular amyloidosis. Ann N Y Acad Sci 903:18-Jun

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