Abstract

This project has three areas of investigation. The applicant proposes initially to study the development of electron dense pigmentary granules which appear in neurons following the digestion of retroviruses by phagosomes. He will also examine the induction of amyloid and neuritic plaques which occurs following the infection of VM mice by the 87A strain of the scrapie agent. These studies will concentrate on the origin, evolution and nature of the amyloid components of the induced plaques. He also proposes to elute immunoglobulins from autopsy-derived Alzheimer diseased brains. Finally, it is noted that the investigator and his associates will provide a considerable amount of support (morphologic evaluations) to the other projects of this proposed program. The techniques involve electron microscopy, immunoelectron microscopy, and immunohistochemistry.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG004342-05
Application #
3821652
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92037

  Publications

Oldstone, Michael B A (2014) Molecular mimicry: its evolution from concept to mechanism as a cause of autoimmune diseases. Monoclon Antib Immunodiagn Immunother 33:158-65
Priola, Suzette A; Ward, Anne E; McCall, Sherman A et al. (2013) Lack of prion infectivity in fixed heart tissue from patients with Creutzfeldt-Jakob disease or amyloid heart disease. J Virol 87:9501-10
Siggs, Owen M; Cruite, Justin T; Du, Xin et al. (2012) Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease. Proc Natl Acad Sci U S A 109:13733-8
Sun, Binggui; Halabisky, Brian; Zhou, Yungui et al. (2009) Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease. Cell Stem Cell 5:624-33
Trifilo, Matthew J; Sanchez-Alavez, Manuel; Solforosi, Laura et al. (2008) Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway. J Virol 82:9890-9
Biasini, Emiliano; Seegulam, M Esa; Patti, Brianna N et al. (2008) Non-infectious aggregates of the prion protein react with several PrPSc-directed antibodies. J Neurochem 105:2190-204
Balch, William E; Morimoto, Richard I; Dillin, Andrew et al. (2008) Adapting proteostasis for disease intervention. Science 319:916-9
Trifilo, Matthew J; Ying, Ge; Teng, Chao et al. (2007) Chronic wasting disease of deer and elk in transgenic mice: oral transmission and pathobiology. Virology 365:136-43
Leclerc, E; Serban, H; Prusiner, S B et al. (2006) Copper induces conformational changes in the N-terminal part of cell-surface PrPC. Arch Virol 151:2103-9
Kunz, Stefan; Rojek, Jillian M; Roberts, Amanda J et al. (2006) Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus. J Virol 80:9082-92

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