It is well recognized that exposure to sunlight is absolutely essential for the development and maintenance of a healthy skeleton in humans when dietary sources of vitamin D are not adequate. Radiation of wavelengths less than 316 nm initiates the production of vitamin D in human skin, a deficiency of which is now being recognized as a health problem amongst the elderly both in Europe and the United States. Sunlight contains a small component of the biologically active UVB wavelengths required for cutaneous vitamin D synthesis and for a generally mobile individual, a normal lifestyle provides sufficient sunlight exposure to maintain a healthy vitamin-D status. However, age is known to decrease the amount of vitamin-D precursor in the skin, and this, together with the lack of outdoor activity undertaken by the elderly and infirm, leads to the bone diseases associated with vitamin-D deficiency. To combat this problem, we need to know how much sunlight exposure throughout the year is required for health. The latter quantity is a function not only of time, but also of skin area exposed, season, and latitude. This study will assess the affect of aging on cutaneous vitamin D synthesis in vivo by monitoring the natural UVB exposure and vitamin-D status of volunteers in a well defined population of elderly in a nursing home setting. Comparison of the (a) solar spectrum with the spectrum with the spectra of fluorescent lights and (b) the capacity of fluorescent lighting to promote cutaneous previtamin D3 synthesis will then enable recommendations to be made for the use of solar irradiation as a means of maintaining adequate vitamin-D nutrition for the elderly mobile residents and for the possible development of UVB-enhanced lighting that could be used in hospital wards and nursing homes for infirm patients who are susceptible to vitamin-D deficiency and cannot go outdoors.
| Thakral, Manu; Shi, Ling; Foust, Janice B et al. (2018) Persistence of pain quality in community-dwelling older adults with chronic non-cancer pain. Geriatr Nurs 39:450-456 |
| van der Leeuw, Guusje; Leveille, Suzanne G; Dong, Zhiyong et al. (2018) Chronic Pain and Attention in Older Community-Dwelling Adults. J Am Geriatr Soc 66:1318-1324 |
| Lipsitz, Lewis A; Manor, Brad; Habtemariam, Daniel et al. (2018) The pace and prognosis of peripheral sensory loss in advanced age: association with gait speed and falls. BMC Geriatr 18:274 |
| Thapa, Saurja; Shmerling, Robert H; Bean, Jonathan F et al. (2018) Chronic multisite pain: evaluation of a new geriatric syndrome. Aging Clin Exp Res : |
| Veronese, Nicola; Cereda, Emanuele; Stubbs, Brendon et al. (2017) Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults: Results from a meta-analysis and exploratory meta-regression analysis. Ageing Res Rev 35:63-73 |
| Nawai, Ampicha; Leveille, Suzanne G; Shmerling, Robert H et al. (2017) Pain severity and pharmacologic pain management among community-living older adults: the MOBILIZE Boston study. Aging Clin Exp Res 29:1139-1147 |
| van der Leeuw, Guusje; Leveille, Suzanne G; Jones, Richard N et al. (2017) Measuring attention in very old adults using the Test of Everyday Attention. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 24:543-554 |
| van der Leeuw, Guusje; Eggermont, Laura H P; Shi, Ling et al. (2016) Pain and Cognitive Function Among Older Adults Living in the Community. J Gerontol A Biol Sci Med Sci 71:398-405 |
| Foley, Jessica M; Salat, David H; Stricker, Nikki H et al. (2016) Glucose Dysregulation Interacts With APOE-?4 to Potentiate Temporoparietal Cortical Thinning. Am J Alzheimers Dis Other Demen 31:76-86 |
| Thakral, Manu; Shi, Ling; Foust, Janice B et al. (2016) Pain quality descriptors in community-dwelling older adults with nonmalignant pain. Pain 157:2834-2842 |
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